王莉莉 1刘海峰 1郭顺林 2郭吉刚 1张浩 1雷军强1
作者信息
- 1. 兰州大学第一医院放射科,兰州,730000
- 2. 兰州大学第一临床医学院,兰州,730000
- 折叠
摘要
Abstract
Objective: To evaluate the value of three-dimensional time of flight magnetic resonance angiography (3D-TOF-MRA) for diagnosing ruptured intracranial aneurysm (RIA) by Meta analysis. Materials and Methods: The studies concerning the diagnosis of RIA by 3D-TOF-MRA until December 2016 were searched in the databases such as CNKI, CBM, Wanfang data, VIP, the Cochrane Library, PubMed,Embase and Web of Science. Two reviewers independently screened literature,extracted data, and assessed risk of bias of included studies by using QUADAS-2 tool.Subsquently, Meta-analysis was performed through Stata 12.0 software. The pooled weighted sensitivity (SEN), specificity (SPE), Positive Likelihood (+LR), Negative Likelihood (-LR) and the diagnostic odds ratio (DOR) were calculated, summary receiver operating characteristic curve (SROC) was drawn. Results: A total of 13 articles consisting 15 studies were included, involving 1004 RIA patients and 1056 suspicious RIA cases. The results of Meta-analysis showed that, the pooled SEN, SPE, +LR, -LR, DOR and AUC of 3D-TOF-MRA for diagnosing RIA were Senmerge=0.94 [95% CI (0.91, 0.97)], Spemerge=0.94 [95% CI (0.87, 0.98)], +LRmerge=9.25 [95% CI (5.28, 16.20)], -LRmerge=0.07 [95% CI (0.05,0.12)],DORmerge=151.90 [95% CI (70.27, 328.37)], AUC=0.98, respectively. Results of subgroup showed 3D-TOF-MRA had better Sen in 3.0 T in comparation with 1.5 T (P<0.05), study type and study standard have no significant differences in RIA diagnosis (P>0.05). Conclusions:3D-TOF-MRA has definite efficiency for assessing RIA, especially in high field study.关键词
颅内动脉瘤/Meta分析/磁共振血管造影术/基于文献的发现Key words
Intracranial aneurysm/Meta-analysis/Magnetic resonance angiography/Literature based discovery分类
医药卫生
