重庆医学2017，Vol.46Issue(25)：3473-3476,4.DOI:10.3969/j.issn.1671-8348.2017.25.006
清气化痰汤对哮喘小鼠肺部炎症的影响
Effect of Qingqihuatan Decoction on pulmonary inflammation in asthmatic mouse
摘要
Abstract
Objective To observe the interventional effect of Qingqihuatan Decoction on airway inflammation and inflammatory reaction of lung tissue in asthmatic mouse.Methods Forty-five BALB/c mice were randomly divided into the normal control group(CON),asthmatic model group(MOD),dexamethasone group(TRE),Qingqihuatan Decoction group(X1) and Qingqihuatan Decoction combined dexamethasone group(X2).The asthmatic mouse model was established by the sensitization and inhalation of OVA and aluminium hydroxide gel.The bronchoalveolar lavage fluid (BALF) was performed the cell counts and eosinophil counts,and the pathological changes of lung tissue were observed.Results Compared with CON group,BALF cell count and eosinophil count in the model group were increased obviously,which in the treatment group were significantly decreased.The effect of the X1 group and X2 group had statistical difference between on 5 d and 15 d.(P＜0.05 or P＜0.01);the treatment groups could reduce the pathogenical infiltration,lung bullae production and airway epithelial thickening of mouse lung tissue,especially the inflammation damage in X2 group was mild.Conclusion Qingqihuatan Decoction can relieve the airway inflammation and improves the lung tissue inflammatory response in model mouse.关键词
哮喘/炎症/清气化痰汤Key words
asthma/inflammation/Qingqihuatan Decoction分类
医药卫生引用本文复制引用
陈竹,彭玉,庞平,杨见辉,罗贞清..清气化痰汤对哮喘小鼠肺部炎症的影响[J].重庆医学,2017,46(25):3473-3476,4.基金项目
贵州省科学技术资金资助项目(黔科合LH字[2014]7314号) （黔科合LH字[2014]7314号）
贵州省卫生和计划生育委员会科学技术基金资助项目(gzwjkj2014-2-124). （gzwjkj2014-2-124）
