重庆医学2017，Vol.46Issue(25)：3542-3546,5.DOI:10.3969/j.issn.1671-8348.2017.25.029
胶质母细胞瘤放疗结合替莫唑胺治疗对比单独放疗的Meta分析
Meta analysis on comparison between radiotherapy combined with temozolomide and single radiotherapy in glioblastoma
李梅 1陈通 1宋向奇 2张卫红 3付爱军 1朱军 1李建民1
作者信息
- 1. 华北理工大学附属医院神经外科,河北唐山063000
- 2. 河北省肃宁县人民医院神经外科 061000
- 3. 华北理工大学附属医院护理部,河北唐山063000
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of radiotherapy combined with concurrent and then adjuvant temozolomide in the patient with glioblastoma.Methods The databases of PubMed,Cochrane library,Medline and OVID were retrieved according to the Cochrane systematical assessment method.The included literatures were performed the quality evaluation and the meta analysis was performed after extracting the data.Results The summary of comparison between temozolomide group and radiotherapy group in the included studies showed that the 12-month overall survival rate[RR 1.22,95 ％ CI(1.01,1.47),P=0.04]and 24-month overall survival rate[RR 2.65,95 ％ CI(1.53,4.40),P＜0.01]had statistically significant differences;the 12-month pregrossion free survival rate[RR 2.59,95 ％CI(1.53,4.40),P=0.000 4] and 24-month pregrossion free survival rate[RR 6.77,95 ％ CI (2.82,16.26),P＜ 0.01] also showed statistically significant difference.The results of adverse reaction events revealed that the hematological toxic reactions in the temozolomide group had statistical difference between the concurrent therapy period and radiotherapy period [RR 3.21,95％CI(1.89,5.46),P＜0.01];which in the temozolomide group had statistical difference between the concurrent period and adjuvant period [RR 0.48,95 ％ CI(0.36,0.65),P＜0.01);but the non-hematological toxic reaction had no statistical difference[RR 1.11,95％CI(0.72,1.70),P=0.64].Conclusion Radiotherapy combined with concurrent and then adjuvant temozolomide therapy improves the overall and progression free survival period in the patient with glioblastoma,the higher occurrence rate of hematologic toxic reactions is correlated with temozolomide treatment drugs.关键词
放射疗法/药物疗法/胶质母细胞瘤Key words
radiotherapy/drug therapy/glioblastoma分类
医药卫生引用本文复制引用
李梅,陈通,宋向奇,张卫红,付爱军,朱军,李建民..胶质母细胞瘤放疗结合替莫唑胺治疗对比单独放疗的Meta分析[J].重庆医学,2017,46(25):3542-3546,5.
