大连理工大学学报2017，Vol.57Issue(5)：441-446,6.DOI:10.7511/dllgxb201705001
曲安奈德在聚丙烯酸酯压敏胶中稳定性研究
Stability of triamcinolone acetonide in polyacrylates press sensitive adhesives
摘要
Abstract
Triamcinolone acetonide is a medium and long-acting glucocorticoid used in treatment of various dermatoses.An HPLC-DAD method is used to detect the stability of triamcinolone acetonide in forced degradation experiment under strong acid/alkali/oxidant condition,and its compatibility with several polyacrylates press sensitive adhesives (PSA).In the forced degradation experiment,the concentrations of triamcinolone acetonide are 100.02％ and 92.47％ in acidic and oxidative conditions respectively,but it completely degrades in the basic condition.Triamcinolone acetonide is stable when the patches use DURO-TAK? 87-2510,87-4098,87-2051 as matrix,but the concentration decreases in case of DURO-TAK? 87-2677,87-2852 or 87-2516 (70.96％,80.38％ and 6.53％ respectively), and no impurity peak is observed in the sample at each experiment wavelength.Then a LC-HRMS method is employed to screen the impurities of triamcinolone acetonide in the samples according to a variety of pharmacopeias, but none of the related substance has been detected. Thus the characteristics of the polyacrylates PSA are compared,and it is assumed that the degradation is caused by the crosslinkers existing in PSA DURO-TAK? 87-2677,87-2852 and 87-2516.关键词
曲安奈德/聚丙烯酸酯压敏胶/交联剂/稳定性Key words
triamcinolone acetonide/polyacrylates press sensitive adhesive/crosslinker/stability分类
医药卫生引用本文复制引用
丁雪,孙玉明,孙盟,石彦瑾,蒲婷婷,陈亚楠,汪晴..曲安奈德在聚丙烯酸酯压敏胶中稳定性研究[J].大连理工大学学报,2017,57(5):441-446,6.基金项目
辽宁省自然科学基金优秀人才培育计划资助项目(2014020015). （2014020015）
