动物营养学报2017，Vol.29Issue(9)：3068-3074,7.DOI:10.3969/j.issn.1006-267x.2017.09.007
肠黏膜上皮组织紧密连接的生物学功能和作用机理
Biological Function and Mechanism of Tight Junction of Intestinal Mucosal Epithelium
陈意 1李方方 1张勇 1黄铁军2
作者信息
- 1. 沈阳农业大学畜牧兽医学院,沈阳 110866
- 2. 乐达(广州)香味剂有限公司,广州 510530
- 折叠
摘要
Abstract
Tight junction is the main connection between intestinal epithelial cells,which plays an important role in maintenance of epithelial cell polarity and regulation of the permeability of the intestinal barrier.Tight junction creates an intercellular barrier limiting paracellular movement of solutes and materials across epithelia.In general,the architecture can be conceptualized into compartments with the transmembrane barrier proteins linked to peripheral scaffolding proteins.Within the complex network,tight junction is associated with many signaling proteins that affect the barrier and broader cell functions.This review was about biological function,molecular mechanisms and current research status of tight junction in intestinal mucosal epithelium.关键词
肠黏膜上皮细胞/紧密连接/黏膜屏障/作用机理Key words
intestinal mucosal epithelial cell/tight junction/intestinal barrier/mechanism分类
农业科技引用本文复制引用
陈意,李方方,张勇,黄铁军..肠黏膜上皮组织紧密连接的生物学功能和作用机理[J].动物营养学报,2017,29(9):3068-3074,7.
