广西医学2017，Vol.39Issue(9)：1295-1298,4.DOI:10.11675/j.issn.0253-4304.2017.09.04
连续性肾脏替代疗法治疗脓毒症的疗效及其对微循环状态的影响
Efficacy of continuous renal replacement therapy for sepsis and its effect on microcirculation
摘要
Abstract
Objective To investigate the efficacy of continuous renal replacement therapy (CRRT) for the treatment of sepsis and its effect on microcirculation .Methods Clinical data of 106 patients with sepsis were analyzed retrospectively , including 53 with CRRT (CRRT group) and another 53 without CRRT(non-CRRT group).The Acute Physiology and Chronic Health Evaluation (APACHE)Ⅱ scores and the relevant parameters of inflammation ,haemodynamics and microcirculation were compared between the two groups .Results After treatment,WBC count,temperature,heart rate,thrombocytocrit,levels of high-sensitivity C-reactive protein and tumor necrosis factor-α, and APACHE Ⅱ scores were all lower than those before treatment , moreover, all of the indicators except for temperature had better improvements in the CRRT group compared to the non-CRRT group(all P<0.05).There were no significant differences in the central venous pressure,mean arterial pressure or oxygenation index between the two groups before and after treatment (P>0.05).After treatment, the blood flow score ,peripheral loop state score ,capillary loop morphology score and total score decreased ,while the top loop vessel diameter increased in the two groups ( all P<0.05) ,and the improvements of all indicators mentioned above in the CRRT group were superior to those in the non-CRRT group(all P<0.05).Conclusion CRRT could significantly improve the infection status of patients with sepsis and promote the recovery of microcirculation .关键词
脓毒症/连续性肾脏替代疗法/微循环/炎症Key words
Sepsis/Continuous renal replacement therapy/Microcirculation/Inflammation分类
医药卫生引用本文复制引用
吴晓文,李军,尧国胜,覃晓洁,黄高..连续性肾脏替代疗法治疗脓毒症的疗效及其对微循环状态的影响[J].广西医学,2017,39(9):1295-1298,4.基金项目
广西自然科学基金(2014GXNSFBA183016) （2014GXNSFBA183016）
