海南医学院学报2017，Vol.23Issue(16)：2180-2183,4.DOI:10.13210/j.cnki.jhmu.20170821.001
乌司他丁联合抗感染治疗对急性重症肺炎患者全身炎症、氧化应激反应的影响
Effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia
摘要
Abstract
Objective: To study the effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia.Methods: A total of 50 patients with acute severe pneumonia who were treated in the hospital were collected and divided into control group and observation group according to the random number table method, 25 cases in each group.Control group received conventional therapy, and the observation group received ulinastatin combined with conventional therapy.The differences in inflammatory response and oxidative stress response in serum were measured before treatment and 10 days after treatment.Results: Before treatment, differences in serum levels of inflammatory response indexes and oxidative stress indexes were not statistically significant between the two groups (P<0.05).After treatment, serum IL-2, IL-6, PCT, HMGB1, CRP, IL-4, IL-10, IL-13, MDA, AOPP and ROS levels of both groups of patients were lower than those before treatment, while SOD, T-AOC, GSH-Px and LHP levels were higher than those before treatment, and serum IL-2, IL-6, PCT, HMGB1, CRP, IL-4, IL-10, IL-13, MDA, AOPP and ROS levels of observation group were lower than those of control group, while SOD, T-AOC, GSH-Px and LHP levels were higher than those of control group (P<0.05).Conclusion: Ulinastatin combined with anti-infective therapy can effectively reduce the systemic inflammatory response and oxidative stress response, and optimize the overall condition in patients with acute severe pneumonia.关键词
急性重症肺炎/乌司他丁/炎症反应/氧化应激Key words
Acute severe pneumonia/Ulinastatin/Inflammatory response/Oxidative stress分类
医药卫生引用本文复制引用
彭洁,安娜,马骏麒..乌司他丁联合抗感染治疗对急性重症肺炎患者全身炎症、氧化应激反应的影响[J].海南医学院学报,2017,23(16):2180-2183,4.基金项目
新疆维吾尔自治区中医民族医药管理局项目(20160402)This study was supported by Project of Administration Bureau of Traditional Chinese Medicine and Ethnic Group Medicine of Xinjiang Uyghur Autonomous Region (20160402). （20160402）
