海南医学院学报2017，Vol.23Issue(16)：2218-2220,2224,4.DOI:10.13210/j.cnki.jhmu.20170816.008
系统性红斑狼疮肾损伤患者血清CRP、血尿酸和免疫球蛋白水平的变化及意义
Changes of serum CRP, serum uric acid and immunoglobulin in patients with renal damage of systemic lupus erythematosus
摘要
Abstract
Objective: To observe the expression of serum CRP, serum uric acid and immunoglobulin (IgG, IgA and IgM) in patients with renal damage of systemic lupus erythematosus, and to explore their clinical application value.Methods: A total of 95 patients with SLE were divided into lupus nephritis group (LN group, n=64) and non-lupus nephritis group (NLN group, n=31) according to the diagnostic criteria of lupus nephritis.Besides, 35 healthy subjects were selected as normal control group.Blood samples were collected from all subjects before treatment.Serum CRP and serum uric acid concentrations were measured by ELISA.The levels of serum immunoglobulins were detected by immunoturbidimetry.Finally, the results were analyzed statistically.Results: The levels of serum CRP and serum uric acid in patients with SLE were significantly higher than those in NLN group and normal control group (P<0.05).The levels of serum CRP and serum uric acid in LN group of SLE patients were significantly higher than those in NLN group and normal control group (P<0.05).The serum CRP level in NLN group was significantly higher than that in normal control group (P<0.05).The serum uric acid level of NLN group was slightly higher than that of the control group, but the difference was not statistically significant (P>0.05).The level of serum immunoglobulin in SLE group was higher than that in normal control group (P<0.05).The levels of serum immunoglobulin IgG, IgA and IgM in LN group of SLE patients were significantly higher than those in NLN group and normal control group (P<0.05).The levels of serum immunoglobulin IgG, IgA and IgM in NLN group of SLE patients were significantly higher than those in normal control group (P<0.05).Conclusions: The humoral immunity of patients with SLE renal injury was activated, with B-cell hyperthyroidism, severe systemic inflammatory response and kidney damage to varying degrees.Serum CRP, serum uric acid and immunoglobulin (IgG, IgA and IgM) may be involved in SLE renal injury pathological process, and they are the reference indicators for the early diagnosis of systemic lupus erythematosus.关键词
系统性红斑狼疮/肾损伤/C反应蛋白/血尿酸/免疫球蛋白Key words
Systemic lupus erythematosus/Renal injury/C-reactive protein/Uric acid/Immunoglobulin分类
医药卫生引用本文复制引用
龙君..系统性红斑狼疮肾损伤患者血清CRP、血尿酸和免疫球蛋白水平的变化及意义[J].海南医学院学报,2017,23(16):2218-2220,2224,4.基金项目
四川省卫生厅科研课题 (125678)This study was supported by the Scientific Research Project of Sichuan Provincial Health Department (Grant No.125678). （125678）
