海南医学院学报2017，Vol.23Issue(16)：2259-2261,2265,4.DOI:10.13210/j.cnki.jhmu.20170816.013
原发性肝癌患者超声剪切波速度与癌细胞生长、病灶内血管新生的相关性研究
Correlation of ultrasonic shear wave velocity with cancer cell growth and intralesional angiogenesis in patients with primary liver
摘要
Abstract
Objective: To study the correlation of ultrasonic shear wave velocity (SWV) with cancer cell growth and intralesional angiogenesis in patients with primary liver cancer.Methods: Patients who were diagnosed with primary liver cancer in Xuzhou Central Hospital were selected, and real-time shear wave elastography was conducted to determine the ultrasonic shear wave velocity;liver cancer lesions and adjacent lesions were collected to determine the expression of tumor suppressor genes, proliferation genes and angiogenesis genes.Results: PICK1, Merlin, PTEN and FN protein expression in liver cancer lesions were significantly lower than those in adjacent lesions, while STC2, N-cadherin, Bcl-2, CyclinD1, E2F, Gli2, VEGFA, MMP9 and Ang-2 protein expression were significantly higher than those in adjacent lesions;liver cancer SWV was negatively correlated with PICK1, Merlin, PTEN and FN protein expression, and positively correlated with STC2, N-cadherin, Bcl-2, CyclinD1, E2F, Gli2, VEGFA, MMP9 and Ang-2 protein expression.Conclusion: The increase of SWV in patients with primary liver cancer is closely related to the cancer cell growth activity and the increase of angiogenesis.关键词
原发性肝癌/超声剪切波速度/增殖/血管新生Key words
Primary liver cancer/Ultrasonic shear wave velocity/Proliferation/Angiogenesis分类
医药卫生引用本文复制引用
刘敏,庞敏..原发性肝癌患者超声剪切波速度与癌细胞生长、病灶内血管新生的相关性研究[J].海南医学院学报,2017,23(16):2259-2261,2265,4.基金项目
江苏省科技计划项目(SBE2015720130)This study was supported by Science and Technology Plan Project in Jiangsu Province (SBE2015720130). （SBE2015720130）
