海南医学院学报2017，Vol.23Issue(16)：2292-2295,4.DOI:10.13210/j.cnki.jhmu.20170816.001
浸润性乳腺癌MRI表观扩散系数与肿瘤组织生长、新生血管生成的相关性
Correlation of MRI apparent diffusion coefficient of invasive breast cancer with tumor tissue growth and angiogenesis
摘要
Abstract
Objective: To study the correlation of MRI apparent diffusion coefficient (ADC value) of invasive breast cancer with tumor tissue growth and angiogenesis.Methods: Patients with breast mass who were treated in Wuhan No.6 Hospital were selected as the research subjects, patients were divided into group A with invasive ductal carcinoma, group B with intraductal carcinoma and group C with benign lesion according to the biopsy results.Magnetic resonance diffusion-weighted imaging was conducted to determine ADC values, and biopsy tissue was taken to determine the expression of proliferation genes and angiogenesis genes.Results: USP39, CyclinD1, VEGF, bFGF, Angplt-2, Angplt-3 and Angplt-4 protein expression levels in lesions of group A and group B were significantly higher than those of group C, while ADC value as well as ALEX1 and Bax protein expression levels were significantly lower than those of group C;USP39, CyclinD1, VEGF, bFGF, Angplt-2, Angplt-3 and Angplt-4 protein expression levels in lesions of group A were significantly higher than those of group B, while ADC value as well as ALEX1 and Bax protein expression levels were significantly lower than those of group B;USP39, CyclinD1, VEGF, bFGF, Angplt-2, Angplt-3 and Angplt-4 protein expression levels in invasive breast cancer tissue with high ADC value were significantly lower than those in invasive breast cancer tissue with low ADC value, while ALEX1 and Bax protein expression levels were significantly higher than those in invasive breast cancer tissue with low ADC value.Conclusion: The decrease of ADC value of invasive breast cancer is closely related to cancer cell proliferation and angiogenesis.关键词
浸润性乳腺癌/磁共振扩散加权成像/表观扩散系数/增殖/血管新生Key words
Invasive breast cancer/Magnetic resonance diffusion-weighted imaging/Apparent diffusion coefficient/Proliferation/Angiogenesis分类
医药卫生引用本文复制引用
付泽鸿,徐红芳,王珺燕..浸润性乳腺癌MRI表观扩散系数与肿瘤组织生长、新生血管生成的相关性[J].海南医学院学报,2017,23(16):2292-2295,4.基金项目
2013湖北省卫计委面上项目(JX6B105)This study was supported by 2013 General Project of Health and Family Planning Commission of Hubei Province (JX6B105). （JX6B105）
