中国实用神经疾病杂志2017，Vol.20Issue(16)：14-16,3.DOI:10.3969/j.issn.1673-5110.2017.16.004
血孤啡肽与脑梗死病情进展及脑梗死后抑郁的相关性
Analysis on correlation between serum orphanin FQ with cerebral infarction and post-stroke depression
摘要
Abstract
Objective To investigate the correlation between serum orphanin FQ with cerebral infarction and post-stroke depression.Methods The peripheral venous blood samples of one hundred and ninety-five patients with cerebral infarction were collected at different time points after the onset.The levels of orphanin in the serum were measured.According to the progress of disease,the patients were divided into the progress group and non-progress group;according to the mental status,the patients were divided into depression and non-depression group.The relationship between HAMD score and limbus orphanin levels was an-alyzed.The location of cerebral infarction and damage of serotonergic neurons in patients were observed by imaging method.The blood orphanin levels in patients with or without impaired serotonergic neurons were compared.Results The level of orphanin in patients with cerebral infarction was not significantly different from that in the healthy population (P >0.05).The level of orpha-nin was gradually higher than that of the healthy group after 24 hours of onset (P <0.05 ).Both progress group and depression group showed significantly higher orphanin level than that of the non-progress group and non-depression group,respectively,and the HAMD score was positively correlated with the levels of orphanin FQ in the depression group.Patients with impaired seroton-ergic neurons had significantly higher ornithine level and higher proportion of depression than that of non-impaired group (P <0.05).Conclusion The upregulation of serum orphanin level can promote the progression and the occurrence of depression after cerebral infarction.关键词
脑梗死/血孤啡肽/脑梗死进展/脑梗死后抑郁Key words
Cerebral infarction/Serum orphanin FQ/Cerebral infarction progress/Post-stroke depression分类
医药卫生引用本文复制引用
唐劭年,谭琦,胡宗继,孙海燕..血孤啡肽与脑梗死病情进展及脑梗死后抑郁的相关性[J].中国实用神经疾病杂志,2017,20(16):14-16,3.基金项目
2014年度东莞市科学技术局科技项目(编号:2014105101013) （编号:2014105101013）
