中国实用神经疾病杂志2017，Vol.20Issue(16)：21-23,3.DOI:10.3969/j.issn.1673-5110.2017.16.006
结核性与化脓性脑膜炎的脑脊液生化指标鉴别诊断
Differential diagnosis of biochemical markers in cerebrospinal fluid in tuberculous meningitis and purulent men-ingitis
摘要
Abstract
Objective To study the application value of biochemical markers in cerebrospinal fluid in differential diagnosis of tuberculous meningitis and purulent meningitis.Methods One hundred and two patients with tuberculous meningitis (TBM group)and 89 patients with purulent meningitis (PM group)in our hospital were selected as the research objects.Protein,sugar, chloride and adenosine deaminase (ADA)in plasma and cerebrospinal fluid (CSF)of all the patients were detected.The ratios of protein,sugar,chloride and ADA in CSF and plasma were calculated and compared.Results Chloride level of CSF in TBM group were significantly lower than those of PM group(P <0.01),ADA level of CSF in TBM group was significantly higher than that of PM group(P <0.01).Protein and chloride level of plasma in TBM group were significantly lower than those of PM group(P <0.01),ADA level of plasma in TBM group was significantly higher than that of PM group(P <0.01 ).The ratio of protein and ADA in TBM group was significantly higher than that of PM group (P <0.05),the ratio of chloride in TBM group was signifi-cantly lower than that of PM group (P <0.01).Conclusion The levels of chloride and ADA in CSF and ratio of protein,ADA and chloride in CSF and plasma have certain application value in the early differential diagnosis of tuberculous meningitis and purulent meningitis.关键词
结核性脑膜炎/化脓性脑膜炎/脑脊液/生化指标/鉴别诊断Key words
Tuberculous meningitis/Purulent meningitis/Cerebrospinal fluid/Biochemical index/Differential diagnosis分类
医药卫生引用本文复制引用
崔俊伟,蔡瑞艳,王永亮..结核性与化脓性脑膜炎的脑脊液生化指标鉴别诊断[J].中国实用神经疾病杂志,2017,20(16):21-23,3.基金项目
河南省科技厅科技攻关计划项目(162102310120) （162102310120）
