临床误诊误治2017，Vol.30Issue(9)：78-81,4.DOI:10.3969/j.issn.1002-3429.2017.09.028
黄葵胶囊联合缬沙坦治疗高血压病早期肾损害临床效果
Clinical Effects of Ambrette Capsules Combined with Valsartan in Treatment of Early Renal Damage in Patients with Hypertension
摘要
Abstract
Objective To investigate clinical effects of Ambrette Capsules combined with Valsartan in treatment of early renal damage in patients with hypertension.Methods A total of hypertension 96 patients with early renal damage admitted during January 2013 and December 2016 were divided into control group and observation group (n=48 for each group) according to their admission order.All patients were treated with conventional therapy and 80 mg/d Valsartan orally.Observation group was added with Ambrette Capsule (5 capsules/time, 3/d) on this basis treatment.Levels of blood pressure, serum creatinine (Scr), urea (BUN), serum cystatin (Cys-C), 24 h urinary protein and superoxide dismutase (SOD) changes were detected after 1 month of treatment, and clinical effects were observed, and incidence rates of adverse reactions were also recorded in two groups.Results Compared with those before treatment, blood pressure, Scr, BUN, Cys-C and 24 h urinary protein levels were significantly decreased, while SOD levels were significantly increased after treatment in the same group in two groups (P<0.05).Compared with those in control group, blood pressure, Scr, BUN, Cys-C and 24 h urinary protein levels were significantly decreased, while SOD level was significantly increased after treatment in observation group (P<0.05).The total effective rate in observation group (95.83％) was significantly higher than 79.17％ in control group (P<0.05).There was no significant difference in incidence rate of adverse reactions between the two groups (P>0.05).Conclusion Ambrette Capsules combined with Valsartan has a certain protective effect on renal function in hypertension patients with early renal damage, and therefore it can be used as the first choice for clinical treatment.关键词
高血压/肾损伤/血管紧张素受体拮抗剂/疗效比较研究Key words
Hypertension/Kidney injury/Angiotensin receptor antagonists/Comparative effectiveness research分类
医药卫生引用本文复制引用
王震,何义先,张静文..黄葵胶囊联合缬沙坦治疗高血压病早期肾损害临床效果[J].临床误诊误治,2017,30(9):78-81,4.基金项目
山东省中医药科技发展计划(2013-059) （2013-059）
