临床误诊误治2017，Vol.30Issue(9)：97-99,3.DOI:10.3969/j.issn.1002-3429.2017.09.034
化疗药物对职业接触护士外周血氧化应激相关指标的影响
Effects of Chemotherapy Drugs on Oxidative Stress of Peripheral Bloods in Vocational Contact Nurses
摘要
Abstract
Objective To observe effects of chemotherapy drugs on relevant indexes of oxidative stress of peripheral bloods in vocational contact nurses.Methods Nurses who worked on departments related to tumor chemotherapy at the end of 2015 were selected as observation group (n=55), and other nurses who worked on clinical departments without contacting tumor chemotherapy drugs at the same period were selected as control group (n=55).Changes of relevant oxidative stress indexes [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and catalase (CAT)] of peripheral bloods were observed in two groups, and correlations between contact time and total professional risk indexes with relevant indexes of oxidative stress of peripheral bloods were analyzed in observation group.Results Compared with those in control group, in observation group, MDA level was significantly increased, while SOD, GSH-Px and CAT levels of peripheral bloods were significantly decreased (P<0.05).Compared with those in short-time contact group (<2.76 years), in long-time contact group, MDA level was significantly increased, while GSH-Px, SOD and CAT levels of peripheral blood were significantly decreased (P<0.05).Compared with those in low-risk group, in high-risk group (occupational risk indexes≥ 285.70), MDA level was significantly increased, while GSH-Px, SOD and CAT levels of peripheral blood were significantly decreased (P<0.05).Conclusion Chemotherapy drugs may obviously affect relevant indexes of oxidative stress of peripheral bloods in vocational contact nurses, and the effect positively correlates with contact time and total professional risk indexes.关键词
化疗药物/护士/超氧化物歧化酶/丙二醛/过氧化氢酶Key words
Chemotherapeutics/Nurses/Super oxide dismutase/Malondialdehyde/Catalase分类
医药卫生引用本文复制引用
潘丹丹,王兰,杨学岩,兆天欣,严丽梅..化疗药物对职业接触护士外周血氧化应激相关指标的影响[J].临床误诊误治,2017,30(9):97-99,3.基金项目
辽宁省科技攻关资助项目(2011225019) （2011225019）
