老年医学与保健2017，Vol.23Issue(4)：283-285,289,4.
青蒿琥酯对糖尿病肾病大鼠Toll样受体及白细胞介素-8表达的影响
Effect of Artesunate on the Expression of Toll-like Receptor and IL-8 in Diabetic Nephropathy Rats
杨志刚 1张南楠2
作者信息
- 1. 福建中医药大学附属人民医院内分泌科,福州350004
- 2. 福建医科大学附属第三医院肿瘤内科,福州350001
- 折叠
摘要
Abstract
Objective To detect the expression of toll-like receptor 4 (TLR4) and interleukine-8 (IL-8) in DN rats so as to explore the protective effect of artesunate on kidney.Methods 80 Wistar rats were randomly divided into 4 groups:normal control group,model control group,high-dose artesunate group and low-dose artesunate group,20 in each;the model of diabetic nephropathy (DN) was set up in rats;1 mL saline/ (kg· d) was applied to rats in normal control group and model control group by gavage;10 mg/ (kg· d) artesunate was applied to rats in low-dose artesunate group by gavage and 30 rag/ (kg· d) to rats in high-dose artesunate group by gavage;8 weeks later,total urine protein in 24 hours,blood creatinine,urea nitrogen,and expression levels of TLR4 and IL-8 in the rats of the 4 groups were detected.Results The rat weight in high-dose and low-dose artesunate group was higher while the kidney hypertrophy index was lower than those in model control group,and the expressions of TLR4 and IL-8 were also lower than those in model control group (P＜0.05).Conclusions Artesunate can effectively control the expression of renal TLR4 protein expression,decrease IL-8 expression,and improve inflammatory response of DN.关键词
青蒿琥酯/糖尿病肾病/类Toll受体4/白细胞介素-8Key words
artesunate/diabetic nephropathy/toll-like receptor 4/interleukin-8引用本文复制引用
杨志刚,张南楠..青蒿琥酯对糖尿病肾病大鼠Toll样受体及白细胞介素-8表达的影响[J].老年医学与保健,2017,23(4):283-285,289,4.
