老年医学与保健2017，Vol.23Issue(4)：316-320,5.
老年排便异常患者血清5-羟色胺及生长抑素与肛门直肠动力学相关性的研究
The Correlation of 5-hydroxytryptamine and Somatostatin with Anorectal Motility in the Elderly with Abnormal Defecation
窦迎春 1马健 1许倩倩 1李青 1徐晓娜 2于新娟 2周长宏 1孟欣颖1
作者信息
- 1. 青岛大学医学院附属青岛市市立医院(东区)干部保健科,青岛市266071
- 2. 青岛大学医学院附属青岛市市立医院(东区)中心实验室,青岛市266071
- 折叠
摘要
Abstract
Objective To detect the levels of 5-hydroxytryptamine (5-HT),somatostatin (SS) in the serum of the elderly with abnormal defecation and the data of anorectal motility so as to explore the correlation.Methods 75 elderly patients were selected during the period from Oct.,2016 to Feb.,2017,including 40 patients with constipation (22 male and 18 female with the average age of 76.1 ±9.4) and 35 patients with diarrhea (19 male and 16 female with the average age of 69.7 ±9.3);enzyme-linked immunosorbent assay (ELISA) was applied in detecting the content of 5-HT and SS in the serum of the patients while anorectal manometry was applied in detecting the data of anal pressure,maximal squeeze pressure of anal,volume of initial sensation,volume of first defecation sensation and maximal tolerable volume;the correlation of the serum content of 5-HT and SS with the data of anorectal motility was described by Pearson correlation coeffecient (PCC).Results The level of SS in the serum of the elderly patients with constipation was negatively correlated to the data of maximal squeeze pressure of anal (maximal squeeze pressure r =-0.402,P ＜ 0.05) and there existed no correlation among other data (P ＞ 0.05);the level of SS in the serum of the elderly male patients with constipation was in negative correlation with the data of maximal squeeze pressure of anal (maximal squeeze pressure r =-0.459,P＜0.05) and there existed no correlation among other data (P＞0.05);the levels of 5-HT and SS in the serum of the elderly patients with diarrhea and those of elderly patients with diarrhea in different gender were of no correlation with the data of anorectal motility (P＞0.05).Conclusions The level of SS may be one of the influence factors on the data of anorectal motility in elderly patients with constipation,and it is of certain effect on data of anorectal motility of elderly male patients with constipation.关键词
排便异常/老年人/5-羟色胺/生长抑素/肛门直肠Key words
abnormal defecation/the elderly/5-hydroxytryptamine (5-HT)/somatostatin (SS)/anorectum引用本文复制引用
窦迎春,马健,许倩倩,李青,徐晓娜,于新娟,周长宏,孟欣颖..老年排便异常患者血清5-羟色胺及生长抑素与肛门直肠动力学相关性的研究[J].老年医学与保健,2017,23(4):316-320,5.
