西华大学学报（自然科学版）2017，Vol.36Issue(5)：57-65,71,10.DOI:10.3969/j.issn.1673-159X.2017.05.009
抗肝细胞癌的小分子靶向药物研究新进展
Recent Progress in Pmall Polecule Pargeted Prug Pesearch for Pepatocellular Parcinoma
摘要
Abstract
Hepatocellular carcinoma ( HCC) is one of the most common malignant tumors in our country. In recent years, with deepening research in HCC pathology and molecular biology mechanism, small molecular drug research targeting HCC has made sub-stantive progress and become one of effective systemic therapies for HCC. This review summarized the reaction mechanism, constitu-tional characteristic and recent progress of small molecule inhibitors in the clinic and clinical stage targeting HCC, including angiogene-sis inhibitors, inhibitors of epidermal growth factor receptor, inhibitors of the key signal transduction passways and epigenetic target in-hibitors. Finally, we proposed that multi-target inhibitors will be the main research direction in the drug development of anti-HCC, and dual targeting epigentic targets and kinases may result in promising therapeutic effects againist HCC.关键词
肝细胞癌/靶向治疗/激酶/表观遗传/多靶点抑制剂Key words
hepatocellular carcinoma/target therapy/kinase/epigenetics/multi-target inhibitor分类
医药卫生引用本文复制引用
徐伟,刘斯宇,李玲,杨羚羚..抗肝细胞癌的小分子靶向药物研究新进展[J].西华大学学报（自然科学版）,2017,36(5):57-65,71,10.基金项目
西华大学校重点项目(项目编号 z1410526) （项目编号 z1410526）
教育部"春晖计划"项目(项目编号16205436). （项目编号16205436）
