生物医学工程研究2017，Vol.36Issue(3)：268-270,276,4.DOI:10.19529/j.cnki.1672-6278.2017.03.16
聚乳酸-羟基乙酸-三亚甲基碳酸酯三元共聚物中单体残留的测定
Determination of Residual DL-Lactide,Glycolidc and 1,3-Trimethylene Carbonate in DL-Lactide-Glycolide-Trimethylene Carbonate Terpolymers
摘要
Abstract
To establish a method of determination of residual DL-lactide (DL-LA), glycolide (GA) and 1,3-trimethylene carbonate (TMC) in DL-lactide-glycolide-trimethylene carbonate terpolymers (PLGA-TMC) by gas chromatography.GsBP-5 capillary column (30 m×0.32 mm, 0.25 μm), and FID detecter were used.The inlet temperature was set 250℃, the temperature of FID was 300℃, the column temperature was kept at 135℃, and the split ratio was 10:1.The results showed that DL-LA, GA and TMC were well separated, the relative standard deviations (RSDs) were all less than 2.0%, each monomer had a good linear relationship in the appropriate concentration range, and the correlation coefficient was not less than 0.999, the average recoveries were 97.17%~101.71%, and the RSDs were less than 5.0%.The method has good specificity and high accuracy, and can be used in the determination of residual monomers and the quality control of PLGA-TMC.关键词
丙交酯/乙交酯/三亚甲基碳酸酯/单体残留/气相色谱法Key words
Lactide/Glycolide/Trimethylene carbonate/Monomer residual/Gas chromatography分类
医药卫生引用本文复制引用
马丽霞,朱爱臣,董浩,刘阳,王宪朋,王勤,王传栋..聚乳酸-羟基乙酸-三亚甲基碳酸酯三元共聚物中单体残留的测定[J].生物医学工程研究,2017,36(3):268-270,276,4.基金项目
山东省重点研发计划项目(2015GSF118089). （2015GSF118089）
