中国组织工程研究2017，Vol.21Issue(25)：4075-4081,7.DOI:10.3969/j.issn.2095-4344.2017.25.023
人脱细胞羊膜在构建组织工程支架中的应用及研究方向
Application of human acelluar amniotic membrane in tissue engineered scaffold construction
摘要
Abstract
BACKGROUND: Human acellular amniotic membrane is a kind of extracellular matrix material with good biocompatibility and biological activity. It has been widely used in various clinical studies because of its low immunogenicity, small rejection and easy preparation.OBJECTIVE: To review the applications of human acellular amniotic membranes in tissue engineering field, such as skin, blood vessel, cornea, cartilage and bone.METHODS: CNKI (from January 2005 to May 2017), CBMdisc (from January 2005 to May 2017), PubMed (from January 1990 to May 2017) and Elsevier (from January 1990 to May 2017) were retrieved for articles addressing the application of human acellular amniotic membrane as a tissue-engineered scaffold in the bone, cartilage, skin, and blood vessels.The keywords were "acelluar amniotic membrane, scaffold, material, tissue engineering ECM" in Chinese and English, respectively.RESULTS AND CONCLUSION: Human acellular amniotic membrane owns the structure and function of the natural extracellular matrix, which can be combined with stem cells from different sources to differentiate into different tissues and organs, such as bone, cartilage, skin, blood vessel, and corneal tissues. As a tissue-engineered scaffold, human acellular amniotic membrane has good biocompatibility, biodegradability and low immunogenicity, although it has some shortcomings, such as poor strength and post-transplantation rejection reactions. Therefore, the future studies are mainly focused on shortening the adhesion time between cells and scaffolds, increasing the own mechanical strength of human acellular amniotic membrane, optimizing the cell growth microenvironment, and combining human acellular amniotic membrane with other tissue-engineered scaffolds.关键词
干细胞/脱细胞羊膜/组织工程/支架/细胞外基质/生物相容性/研究进展/修复/重建/免疫分类
医药卫生引用本文复制引用
杨继滨,熊华章,李豫皖,刘毅..人脱细胞羊膜在构建组织工程支架中的应用及研究方向[J].中国组织工程研究,2017,21(25):4075-4081,7.基金项目
贵州省科技厅社会发展科技攻关项目(黔社科合SY字[2010]3091) （黔社科合SY字[2010]3091）
贵州省科学技术基金资助项目(黔科合LH字[2016]7477号) the Science & Technology Program of Guizhou Province, No. SY[2010]3091 （黔科合LH字[2016]7477号）
the Science & Technology Program of Guizhou Province, No. LH[2016]7477 （）
