中国组织工程研究2017，Vol.21Issue(25)：4094-4100,7.DOI:10.3969/j.issn.2095-4344.2017.25.026
骨髓坏死综合征:研究发展近况
Current status of research on bone marrow necrosis syndrome
摘要
Abstract
BACKGROUND: Bone marrow necrosis has unspecific clinical features, which is often misdiagnosed or missed due to a lack of the knowledge of the disease. OBJECTIVE: To improve the awareness and vigilance to bone marrow necrosis, and to further explore the clinical manifestations, hematological characteristics, pathogenesis and treatment of bone marrow necrosis. METHODS: The "bone marrow necrosis, hematologic neoplasms, solid tumor, bone marrow puncture, bone marrow pathology" in Chinese and English served as the search terms to search articles related to bone marrow necrosis in PubMed and Wanfang databases, published from 1941 to 2016. Totally 43 articles were selected for review. RESULTS AND CONCLUSION: Bone marrow necrosis is a rare complication caused by various diseases, clinically characterized by bone pain, fever, anemia, and nucleated red cells and immature neutrophilic leukocytes in the blood smear. Bone marrow aspiration and/or bone marrow biopsy show(s) necrotic features. Its pathogenesis is complex, and it is still poorly understood and needs further research. There is no good treatment for bone marrow necrosis, and the prognosis is poor. Early correct diagnosis and etiological treatment are crucial for the prognosis of bone marrow necrosis.With the improvement of disease awareness, bone marrow cytology, genetics, MRI and hematopoietic stem cell transplantation, bone marrow necrosis is expected to get a better prognosis.关键词
干细胞/骨髓干细胞/骨髓坏死/血液肿瘤/实体肿瘤/骨髓穿刺/骨髓病理分类
医药卫生引用本文复制引用
毛慧,贾文华,黄一虹,李德鹏..骨髓坏死综合征:研究发展近况[J].中国组织工程研究,2017,21(25):4094-4100,7.基金项目
江苏省卫生科研项目(H201427) （H201427）
江苏省2016年度普通高校研究生科研创新计划(SJZZ16_0288) （SJZZ16_0288）
徐州市科技计划项目(KC16SH016) the Health Science Research Project of Jiangsu Province, No. H201427 （KC16SH016）
the Postgraduate Innovative Research Plan of Jiangsu Province High Educations in 2016, No. SJZZ16_0288 （）
the Scientific Research Plan of Xuzhou City, No. KC16SH016 （）
