新医学2017，Vol.48Issue(9)：638-643,6.DOI:10.3969/j.issn.0253-9802.2017.09.010
佛山地区儿童过敏性疾病常见致敏过敏原分布——附7157例报告
Distribution of common sensitizing allergens in 7 157 children with allergic diseases from Foshan
摘要
Abstract
Objective To analyze the distribution pattern of sensitizing allergens in children with allergic diseases from Foshan.Methods A total of 7 157 children with allergic diseases from Foshan were divided into the infant (aged 0-2.9 years, n=2 591), pre-school age (aged 3-5.9 years, n=3 541) and school age groups (aged 6-14 years, n=1 025).The positive rates of 19 types of aeroallergens and food specific allergens (sIgE) in the serum were detected by Allergy Screen allergen quantitative detection system (MEDIWISS, Germany).The distribution pattern of different allergens among four seasons was analyzed.Results Among 7 157 affected children, 4 666 cases were positive for one or more allergen sIgE. The most common aeroallergens were dust mites (45.07%), dog dander (29%) and cat dander (23.94%). The dominant food allergens included milk (44.51%), chicken egg white (14.81%) and cashew nuts (13.89%). In the infant group, the most common allergens were milk (61.51%), cat dander (38.30%) and dog dander (36.63%), and dust mites (54.27%), milk (40.39%) and dog dander (26.68%) in the pre-school age group, and dust mites (70.34%), dust (23.09%) and milk (20.49%) in the school age group. The positive rates of dust mites and milk significantly differed among different groups (all P <0.017). The distribution pattern of allergens significantly differed among four seasons. The positive rate of dust mites in summer was significantly higher compared with those in the other three seasons, and the positive rate of dog dander in winter was considerably lower than those in the other seasons (all P <0.008). Conclusions House dust mite, milk, dog and cat dander and chicken egg white are the primary allergens in children with allergic diseases from Foshan. The distribution pattern of varying allergens significantly differs based upon age and season.关键词
过敏性疾病/过敏原特异性IgE/儿童Key words
Allergic disease/Allergen-specific IgE/Children引用本文复制引用
陈晓倩,黎雅婷,钟韩荣,潘莉,杨丽芬,蔡亮鸣,王昭妮,陈壮桂..佛山地区儿童过敏性疾病常见致敏过敏原分布——附7157例报告[J].新医学,2017,48(9):638-643,6.基金项目
国家自然科学基金面上项目(81470219) （81470219）
广东省科技计划项目基金(2014A020212120) （2014A020212120）
