眼科新进展2017，Vol.37Issue(9)：890-893,4.DOI:10.13389/j.cnki.rao.2017.0226
糖尿病视网膜病变中视网膜小胶质细胞活化及干预机制研究进展
Recent advances in microglia activation and intervention mechanism in diabetic retinopathy
摘要
Abstract
Diabetic retinopathy (DR) is one of the most significant microvascular complications of diabetes,and its incidence increases with the prolongation of DM;meanwhile,it can lead to severe vision loss.Recently,the pathogenesis of DR has been one of the focuses both at home and abroad,but the basic mechanisms are not fully elucidated.More and more scholars believe that DR may be a chronic and low degree of inflammatory response.Moreover,it is well established that microglia is a monocyte-macrophage,with antigen-presenting function.Especially in the retina,as microglia is activated,followed by the release of a large number of inflammatory factors,microglia involves in DR inflammatory response.Understanding the activation mechanism of microglia can provide a new perspective for the prevention and treatment of DR.Therefore,recent advances in activation of microglia in diabetic retinopathy and its intervention mechanism will be reviewed in the article.关键词
糖尿病视网膜病变/小胶质细胞/活化/干预Key words
diabetic retinopathy/microglia/activation/intervention分类
医药卫生引用本文复制引用
张悦,董宁..糖尿病视网膜病变中视网膜小胶质细胞活化及干预机制研究进展[J].眼科新进展,2017,37(9):890-893,4.基金项目
国家自然科学基金资助(编号:81400405)National Natural Science Foundation of China (No:81400405) （编号:81400405）
