中国比较医学杂志2017，Vol.27Issue(9)：24-29,6.DOI:10.3969.j.issn.1671-7856.2017.09.005
非人灵长类评价学习记忆功能的影响因素探讨
Investigation of influencing factors on the evaluation of learning and memory in nonhuman primates
摘要
Abstract
Objective The delayed?response task based on the Wisconsin General Testing Apparatus ( WGTA) is commonly used to evaluate the ability of learning and memory in nonhuman primates. Because the task may be influenced by a number of factors, how to set and standardize the parameters during the training and evaluation stage is of great signifi?cance and value for obtaining appropriate results of learning and memory ability. Methods In this study, 8～9 years old male cynomolgus macaques ( Macaca fascicularis) were tested with the modified WGTA. We evaluated the influence of ex?perimental factors such as the times of training, frequency of evaluation, interval time of evaluation, delayed time and num?ber of stimulus trays on the results of learning and memory ability in the macaques by investigating the correct rates of food acquiring. Results The correct rate of food acquiring of the cynomolgus macaques was unstable and significantly decreased when the times of training was less than 10 during the training stage. The frequency of evaluation had less effect on the correct rate on the basis of enough training. The correct rate of food acquiring was still above 65％ with a 3?month interval after training. However, the increase of delayed time led to significant decrease of the correct rate in some ma?caques. In addtion, more than 3 stimulus trays also resulted in a low correct rate in general less than 65％. Conclusions Reasonable designing of the experimental parameters during the training and evaluation stage is important for determining the learning and memory ability in nonhuman primates.关键词
非人灵长类/学习记忆/训练/评价Key words
Nonhuman primates/Learning and memory/Training/Evaluation分类
医药卫生引用本文复制引用
李舸,张钰,刘晓霖,陈锐,刘书华,李韵峰,关雅伦,李雪娇,裴中,黄韧..非人灵长类评价学习记忆功能的影响因素探讨[J].中国比较医学杂志,2017,27(9):24-29,6.基金项目
广东省科技计划项目(编号:2014B040404053,2015A020212027). （编号:2014B040404053,2015A020212027）
