中国比较医学杂志2017，Vol.27Issue(9)：41-47,7.DOI:10.3969.j.issn.1671-7856.2017.09.008
土大黄根提取物对实验性银屑病小鼠组织器官形态学的影响
Effects of Rumex L. root extract on the morphology of skin and some organs in mouse model of experimental psoriasis
摘要
Abstract
Objective To explore the effects of Rumex L. root extract on the morphology of tissues and organs in the mice of experimental psoriasis. Methods The experimental psoriasis model was established in BALB/c mice receiving commercially available imiquimod cream (5％ IMQ) on the shaved back (dorsal) for 6 consecutive days. The drugs (posi?tive controls and rumex L. root extract) were intragastrically administered at the volume of 0. 2 mL/10 g. And then the effects of the positive control drugs (DXM, XYKL, MB) and the Rumex L. root extract (1, 2, 4 g/kg) on the morphology of the dorsal skin tissues, thymus, marrow and spleen, as well as the organ indexes of thymus and spleen were observed. Results Compared with the model group, epithelial thickening and parakeratosis of the mice in the 1 g/kg group were still visible. As for the mice in the 2 g/kg group, most epithelial returned to normal and there was also a visible area of epithe?lial thickening. As for the mice in the 4 g/kg group, most epithelial returned to normal and there were individual differ?ences among the mice. Compared with the positive control groups ( DXM, XYKL, MB) , epithelial thickening and paraker?atosis of the mice in the 1 g/kg group were still visible. In the 2 g/kg group, the changes of dorsal skin of the mice were similar to the XYKL and MB positive control groups. In the 4 g/kg group, the changes of dorsal skin of the mice were simi?lar to the DXM positive control group. And there was no obvious abnormality of thymus, marrow and spleen morphology in the blank control group, the model group, the positive control groups and the Rumex L. root extract?treated groups (1, 2, 4 g/kg) . Compared with the model group, the organ indexes of thymus and spleen were decreased in the DXM group ( P<0. 01) and there was no significant difference in the XYKL group, the MB group and the Rumex L. root extract?treated groups (1, 2, 4 g/kg) (P> 0. 05). Compared with the DXM positive control group, the organ indexes of thymus and spleen were increased in the Rumex L. root extract?treated groups (1, 2, 4 g/kg) (P< 0. 01). Conclusions Rumex L. root extract can inhibit the IMQ?induced histological changes of mouse dorsal skin in a dose?dependent manner, but there are no obvious effects on the morphology of thymus, marrow and spleen.关键词
土大黄根/实验性银屑病/组织器官/形态学Key words
Root of Rumex L/Experimental psoriasis/Tissues and organs/Morphology分类
医药卫生引用本文复制引用
艾西木江·热甫卡提,尤力都孜·买买提,阿不都热衣木·肉孜,热比姑丽·伊斯拉木..土大黄根提取物对实验性银屑病小鼠组织器官形态学的影响[J].中国比较医学杂志,2017,27(9):41-47,7.基金项目
新疆维吾尔自治区卫生计生委青年科技人才专项科研项目(编号:2015Y40). （编号:2015Y40）
