中国比较医学杂志2017，Vol.27Issue(9)：92-97,6.DOI:10.3969.j.issn.1671-7856.2017.09.018
抑郁症动物模型的研究进展
Research progress on animal models of depression
摘要
Abstract
The incidence of depression has been increasing over the recent years, which can cause serious physical and mental health problems in humans, but its pathogenesis has not been fully clarified. Animal models can simulate the depression in humans, thus are widely used for studies of the pathogenesis of depression, as well as in research and devel?opment of new antidepressants. According to the different ways of modeling, animal models of depression can be divided in?to the following categories: stress models, surgical models, drug?induced models and genetic models. These models can provide useful tools to explain some pathogenetic aspects of depression, such as neurotransmitters and their receptors/trans?porters, neurotrophic factors, neuroendocrine systems, inflammatory hypotheses, and so on. This review summarizes and e?valuates the commonly used rodent animal models of depression and provides a reference for further research on depression.关键词
抑郁症/啮齿类/动物模型/发病机制Key words
Depression/Rodent/Animal models/Pathogenesis分类
医药卫生引用本文复制引用
张磊阳,贺敏,李玥,裘福荣,陈文文,吴雨,杨蒋伟,蒋健..抑郁症动物模型的研究进展[J].中国比较医学杂志,2017,27(9):92-97,6.基金项目
上海市进一步加快中医药事业发展三年行动计划(编号:ZY3-CCCX-3-2007). （编号:ZY3-CCCX-3-2007）
