中国循证儿科杂志2017，Vol.12Issue(4)：251-256,6.DOI:10.3969/j.issn.1673-5501.2017.04.003
体素内不相干运动弥散加权成像对儿童腹部良恶性肿瘤诊断价值
Value of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging in differentiating benign and malignant pediatric abdominal tumors
摘要
Abstract
ObjectiveTo investigate the value of IVIM double exponential parameters in differentiating the benign and malignant pediatric abdominal tumors by use of the method of IVIM DW-MRI.MethodsTaking the pathology of pediatric abdominal tumor operation specimens as the golden standard, patients were assigned to malignant group, benign solid group, borderline group and benign cystic group, and the IVIM DW-MRI detection was performed as the standard to be detected within one week before the operation, and routine MRI (T1W, T2W, CE-T1W) and DWI sequence examination were performed for the suspected abdominal tumor, which could not be confirmed as the benign tumor.Then the b value range of 0~800 s·mm-2 was chosen, and the ADC value was obtained by the software calculation, and the tumor size was delineated by use of ROI tumor profile method, and the D, D* and f values were calculated.Results85 cases of children with abdominal tumor (98 masses) were included in the analysis of this study and there were 43 cases of male patients with the average age of 4.4 years old;malignant group (52 cases, 62 masses), borderline group (7 cases, 7 masses), benign solid group (21 cases, 24 masses), benign cystic group (5 cases, 5 masses);and the average value of ROI was 12.9(1.3~26.1)cm2.And for ADC, D and D* values, they showed the lowest in the malignant group and increased successively in the borderline group, benign solid group and benign cystic group, which had statistically significant difference;the differences of ADC, D and D* values between the malignant group and non-malignant (benign solid, borderline and benign cystic) groups had statistical significance;the cutoff identifying malignant and benign solid tumors was 1 367, 1 056 and 1 605 ×10-6mm2·s-1, respectively, and the identifying specificity for ADC was higher (85.5%), and the identifying sensitivity for D value was higher (83.3%), and the cutoff identifying malignant and solid tumors (benign solid plus borderline), malignant and non-malignant (benign solid plus borderline plus benign cystic) was 1 173, 1 014 and 1 634×10-6mm2·s-1, respectively;the specificity for ADC and D values identifying malignant and solid tumors (benign solid plus borderline) was better (87.1% and 83.9%), and the specificity for ADC, D and D* values identifying malignant and non-malignant (benign solid plus borderline plus benign cystic) was all better (88.9%,86.1% and 80.6%).Conclusion The ADC and D values in the IVIM DW-MRI had good diagnostic value in identifying pediatric abdominal benign and malignant tumors.关键词
磁共振成像/弥散加权/体素内不相干运动/腹部肿瘤/手术病理/儿童Key words
Magnetic resonance imaging/Diffusion-weighted imaging/Intravoxel incoherent motion/Abdominal tumor/Pathology of operation/Children引用本文复制引用
徐燕清,王莉,龚英,马阳阳,周剑,乔中伟..体素内不相干运动弥散加权成像对儿童腹部良恶性肿瘤诊断价值[J].中国循证儿科杂志,2017,12(4):251-256,6.基金项目
上海市科学技术委员会西医引导项目:134119a4100 （）
上海申康医院发展中心临床辅助科室能力(影像医学)建设项目:SHDC22015031 （影像医学）
