中国中西医结合影像学杂志2017，Vol.15Issue(5)：515-519,5.DOI:10.3969/j.issn.1672-0512.2017.05.002
偏头痛风火候患者静息状态下脑功能连接的初步探讨
Rudimen analysis of connectivity changes in migraine's disease with feng-huo type in resting state
摘要
Abstract
Object:Imageology study has shown that the brain structure and function in patients with migraine of feng-huo type have changed. This study used the characteristic of spontaneous neuronal activity in patients with migraine of feng-huo type to discuss resting state functional magnetic resonance imaging technology. The research also analyzed the change of migraine rest-ing state brain functional connectivity. It can give us a better understanding of the pathogenesis of migraine of feng-huo type. Methods:Incorparate 30 patients with migraine of feng-huo type,and also choose 30 healthy persons. They had the same age, gender,and education level. Compare the differences among them. Let them make resting state fMRI scan. Then use ReHo analysis and functional connectivity analysis to analyze the two kinds of methods of data processing:①ReHo analysis:through analyzing the differences of the two tested groups of ReHo in different brain regions to find out the different brain regions. Then use REST 1.8 single sample and two sample T test to find differences in brain areas. ②FC analysis:select differences in brain regions of local consistency analysis as the seed point,analyze the seed point and the whole brain function connectivity. Results:①The differences between migraine were in brain regions of ReHo for left cerebellum,left frontal straight back,right frontal lobe,right outside the dorsolateral frontal gyrus,the left edge of the leaf. ②Compared with healthy controls,the region of interest and whole brain functional connectivity showed that the functional connectivity of migraine patients with gout condition of heat left cerebellum and left superior temporal gyrus,left inferior parietal lobule,right insula decreased functional connectivity (P<0.05);the functional connectivity of the left orbital lobes straight back and right fusiform gyrus had decreased (P<0.05);the function of the right frontal lobe;outer connected with the right cerebellum,left superior frontal gyrus weaken. The functional connectivity of the frontal orbital region,right premotor area had increased (P<0.05). The functional connectivity of the right dorsolateral frontal gyrus and left precentral gyrus had decreased,connected with the foot back function enhancement of the right inferior temporal gyrus,the lower (P<0.05). The left edge of the leaf and whole brain functional connectivity were without difference. Conclusion:The patients with migraine of feng-huo type headache interval function appear abnormal brain regions. The pathogenesis of these findings contribute to the understanding of migraine of feng-huo type.关键词
偏头痛/风火候/静息态功能磁共振/功能连接Key words
migraine/feng-huo type/resting-state functional magnetic resonance imaging/functional connectivity引用本文复制引用
吴宏赟,梁延琛,侯金萍,李春林..偏头痛风火候患者静息状态下脑功能连接的初步探讨[J].中国中西医结合影像学杂志,2017,15(5):515-519,5.基金项目
山东省自然基金项目(ZR2014CL013,ZR2015HL106). （ZR2014CL013,ZR2015HL106）
