中国中西医结合影像学杂志2017，Vol.15Issue(5)：541-543,3.DOI:10.3969/j.issn.1672-0512.2017.05.009
醛糖还原酶抑制剂对早期糖尿病肾病患者 肾血流动力学参数的影响
Effect of aldose reductase inhibitor on renal blood flow parameters of early diabetic nephropathy
摘要
Abstract
Objective:To investigate the effect of early diabetic nephropathy treated with aldose reductase inhibitors/epalrestat, and observe the change of renal blood flow parameters. Methods:120 early diabetic nephropathy patients were randomly as-signed to control group and treatment group,68 and 52 cases. All patients were treated for 3 months. The control group was not treated with ARI,and the treatment group was treated with ARI,and the parameters of renal blood vessels before and after treatment were measured by color high resolution ultrasound system. SPSS 16.0 software was used for statistical treatment. Re-sults:Age,course of disease,FBG,DBP,SBP,SUA,LDL,TG,TC,HDL,WC and BMI were similar before and after the treatment, There was no significant difference (P>0.05). After 3 months of treatment,the treatment group of renal artery and renal artery end diastolic velocity (EDV) were significantly higher than the control group (P<0.01),treatment group with lobar artery peak systolic velocity (PSV) and EDV levels were significantly higher than the control group (P<0.01). The blood flow resistance index (RI) was significantly lower than that of the control group (P<0.01). Conclusion:Aldose reductase inhibitor/epalrestat can improve the blood flow of renal artery of early DN,increase renal artery perfusion,improve glomerular microcirculation,ef-fectively delay the progression of renal disease.关键词
醛糖还原酶抑制剂/依帕司他/糖尿病肾病/血流动力学Key words
Aldose reductase inhibitors/Epalrestat/Diabetic nephropathies/Hemodynamic引用本文复制引用
刘春泥,袁玉红,石秀娟,饶小胖..醛糖还原酶抑制剂对早期糖尿病肾病患者 肾血流动力学参数的影响[J].中国中西医结合影像学杂志,2017,15(5):541-543,3.基金项目
青岛市优秀医学人才计划项目(2015040). （2015040）
