中国中医药信息杂志2017，Vol.24Issue(10)：133-136,4.DOI:10.3969/j.issn.1005-5304.2017.10.036
从痰论治激素性股骨头坏死OPG/RANK/RANKL信号调控机制研究进展
Research Progress in OPG/RANK/RANKL Signal-regulated Mechanism of Steroid Induced Avascular Necrosis of Femoral Head from Phlegm Theory
摘要
Abstract
In recent years, due to the irregular and abused use of glucocorticoid in clinical treatment, the incidence of steroid induced avascular necrosis of femoral head (SANFH) is gradually increasing. TCM for the prevention and treatment of SANFH has received much attention from many scholars. However, due to the lack of the scientific explanation of molecular biology level for its pharmacodynamics mechanism, it is difficult to achieve the purpose of standardized treatment. The discovery of OPG/RANK/RANKL signaling pathway has opened up new shortcuts for the prevention and treatment of bone metabolic diseases. OPG/RANK/RANKL signaling pathway is associated with the pathogenesis of "spleen deficiency and phlegm - blood stasis caused by phlegm-blood stasis due to paralysis" of SANFH. The treatment efficacy based on the phlegm theory can eventually axial control of the system through the micro-information to express. This article discussed the relevance between the "phlegm" in the treatment of SANFH and molecular biology mechanism of OPG/RANK/RANKL signal regulation mechanism, and combined the system of bone metabolism regulation mechanism to discuss TCM differentiation of SANFH, with a purpose to provide references for clinical and further study.关键词
激素性股骨头坏死/OPG/RANK/RANKL信号通路/从痰论治/机制/综述Key words
steroid induced avascular necrosis of femoral head/OPG/RANK/RANKL signaling pathway/phlegm theory/mechanism/review分类
医药卫生引用本文复制引用
汪小敏,曹林忠,宋敏,李俊,赵希云,刘新宇,苏亮磊..从痰论治激素性股骨头坏死OPG/RANK/RANKL信号调控机制研究进展[J].中国中医药信息杂志,2017,24(10):133-136,4.基金项目
甘肃省自然科学基金(1308RJZA293) （1308RJZA293）
甘肃省卫生行业科研管理项目(GWGL2014-65) （GWGL2014-65）
甘肃中医药大学中青年基金(ZQ2014-13) （ZQ2014-13）
