中山大学学报（医学科学版）2017，Vol.38Issue(5)：746-751,6.
长非编码RNA GAS5在卵巢癌患者中的低表达及其临床意义
Decreased Expression of Long Non-Coding RNA GAS5 in Ovarian Cancer Patients and Its Clinical Significance
李婕 1李银广 1陈爱月 1李珠玉 2侯文汇 2游泽山2
作者信息
- 1. 中山大学附属第一医院东院妇产科 广东广州510700
- 2. 中山大学附属第一医院妇产科 广东广州510080
- 折叠
摘要
Abstract
[Objective]Dysregulated long noncoding RNAs(lncRNAs)have been found involved in human diseases,including cancers. Long non-coding RNA growth arrest-specific 5(GAS5)was reported to be dysregulated in different types of cancers. Howev-er,the role of GAS5 in ovarian cancer remains elusive.[Methods]In the present study,the expression of GAS5 was detected in 108 ovarian cancer tissues and compared adjacent normal tissues by quantitative real-time PCR(qRT-PCR).[Results]The results showed that the expression levels of lncRNA GAS5 were significantly decreased in cancer tissues(P=0.0004),and it was negatively correlated with tumor size(<5 cm vs.>5 cm,P<0.0001),invasion depth(T1-T2 vs. T3-T4,P=0.0021),and tumor grade(Ⅰ~Ⅱgrades vsⅢ~Ⅳgrades,P=0.0086)in ovarian cancer patients. Kaplan-Meier analysis demonstrated that decreased lncRNA GAS5 expression contributed to poor disease-free survival and overall survival.[Conclusion]In conclusion ,our study suggested that decreased lncRNA GAS5 expression may beidentified as a potential poor prognostic biomarker in ovarian cancer.关键词
长非编码RNAGAS5/卵巢癌/临床意义Key words
long non-coding RNA GAS5/ovarian cancer/clinical significance分类
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李婕,李银广,陈爱月,李珠玉,侯文汇,游泽山..长非编码RNA GAS5在卵巢癌患者中的低表达及其临床意义[J].中山大学学报（医学科学版）,2017,38(5):746-751,6.
