中国现代中药2017，Vol.19Issue(7)：924-928,5.DOI:10.13313/j.issn.1673-4890.2017.7.005
不同道地产区蒙古黄芪抗疲劳作用比较研究
Anti-fatigue Effects of Astragalus membranaceus (Fisch.) Beg.var.mongholicus (Beg.) Hsiao from Different Genuine Habitats on Mice
摘要
Abstract
Objective:The anti-fatigue effects of Astragalus membranaceus (Fisch.) Beg.var.mongholicus from different habitats were studied in this research.The samples of wild and cultivated A.membranaceus var.mongholicus were collected from Shanxi Hunyuan,Inner Mongolia Wuchuan and Inner Mongolia Tumoteyouqi.Methods:Exhaustive swimming exercise:18 ～22 g KM mice were used and administered orally by dose of 5 g ·kg-1 and 10 g ·kg-1 for4 weeks.One hour after the last administration,put mice into water (16 cm× 16 cm ×20 cm,(25 ± 1) ℃) with 10％ bodyweight iron wire on the tail,recording the swimming time until the mice sank for 10 s.90 min swimming exercise:Mice were treated as described above.One hour after the last administration,put mice into water (16 cm × 16 cm ×20 cm,(25 ± 1) ℃2) and let them swim for 90 min,then lactic dehydrogenase,blood urea nitrogen,lactic acid,and hepatic glycogen were tested.Results:The results indicated that A.membranaceus var.mongholicus from all these habitats could significantly extend mice exhaustive swimming time,increase the liver glycogen and blood lactate dehydrogenase after swimming,decrease the blood lactic and blood urea nitrogen level after swimming.The swimming timne of each low dose group was:Hunyuan (522.0 ± 81.5) s,Wuchuan (613.4 ±55.7) s,Tumoteyouqi wild (508.2 ±61.0) s,Tumoteyouqi cultivated (484.5 ±40.7) s;the swimming time of each high dose group is:Hunyuan (599.7 ± 48.6) s,Wuchuan (790.3 ± 57.1) s,Tumoteyouqi wild (575.7 ± 73.7) s,Tumoteyouqi cultivated (544.1 ± 74.9) s,and Wuchuan group is significantly longer than the other three groups.The liver glycogen of each low dose group was:Hunyuan (26.81 ± 1.04) mg ·g-1,Wuchuan (31.67 ±2.87) mg ·g-1 、Tumoteyouqi Wild (22.31 ± 2.38) mg ·g-1,Tumoteyouqi Cultivated (22.96 ± 1.95) mg ·g-1,the liver glycogen of each high dose group was:Hunyuan (30.89 ± 3.35) mg· g-1,Wuchuan (39.56 ± 3.44) mg · g-1,Tumoteyouqi wild (29.52 ± 1.43) mg · g-1 Tumoteyouqi cultivated (28.41 ± 2.06) mg ·g-1.Conclusion:The swimming time of all the four groups was prolonged remarkably,and Wuchuan A.membranaceus var.mongholicus showed best anti-fatigue effects.There was no significant difference between cultivated and wild A.membranaceus var.mongholicus from Tumoteyouqi.关键词
蒙古黄芪/道地产地/抗疲劳/力竭游泳/肝糖原Key words
Astragalus membranaceus (Fisch.) Beg.var.mongholicus (Beg.) Hsiao/genuine habitats/anti-fatigue effects/exhaustive swimming exercise/hepatic glycogen引用本文复制引用
闫暾,任凯,白小荣,张春红,李旻辉..不同道地产区蒙古黄芪抗疲劳作用比较研究[J].中国现代中药,2017,19(7):924-928,5.基金项目
名贵中药资源可持续利用能力建设项目(2060302) （2060302）
公益性行业科研专项(201507002) （201507002）
内蒙古自治区科技创新引导项目(内蒙古地区5种道地药材种质资源保护、特色栽培加工技术规范的制定及推广应用) （内蒙古地区5种道地药材种质资源保护、特色栽培加工技术规范的制定及推广应用）
内蒙古自治区科技计划项目(蒙药资源保护与开发利用科研创新平台) （蒙药资源保护与开发利用科研创新平台）
