儿科药学杂志2017，Vol.23Issue(9)：1-4,4.DOI:10.13407/j.cnki.jpp.1672-108X.2017.09.001
病毒性脑炎患儿脑脊液和血清中IFN-α和S100B蛋白的表达及临床意义
Expression and Clinical Significance of IFN-α and S100B Proteins in Cerebrospinal Fluid and Serum of Children with Viral Encephalitis
摘要
Abstract
Objective:To investigate the clinical significance and expression of IFN-α and S100B proteins levels in cerebrospinal fluid and serum in children with viral encephalitis.Methods:Eighty children with viral encephalitis were selected as observation group from our hospital,and at the same time 50 healthy children were selected as control group.The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum were compared between the two groups.The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum were compared in different symptoms,phases and prognosis.Results:Compared with the control group,the levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in observation group were significantly increased,the differences were statistically significant (P＜0.01).The levels of IFN-oα and S100B proteins in cerebrospinal fluid and serum in severe group were significantly higher than the mild group (P＜0.01).The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in recovery phase were significantly lower than those in acute phase (P＜0.01).The 1 year follow-up showed that the levels of IFN-α and S100B proteins in cerebrospinal fluid and serum of children with poor prognosis were significantly higher than those with good prognosis (P＜0.01).Multivariate linear regression analysis showed that the severe and acute phases were independent risk factors affecting the rise of IFN-α and S100B proteins levels (P＜0.05).Conclusion:The changes of IFN-α and S100B proteins in cerebrospinal fluid and serum have important clinical value in the evaluation of the condition and prognosis of viral encephalitis.关键词
病毒性脑炎/α干扰素/S100B蛋白/脑脊液Key words
viral encephalitis/IFN-α/S100B proteins/cerebrospinal fluid分类
医药卫生引用本文复制引用
胡伟伟,刘志广,李伟,袁方,刘丙丽,刘君,朱亮,王江波,曹培卫..病毒性脑炎患儿脑脊液和血清中IFN-α和S100B蛋白的表达及临床意义[J].儿科药学杂志,2017,23(9):1-4,4.基金项目
徐州市科技项目,编号 KC14SH029. （）
