肝胆胰外科杂志2017，Vol.29Issue(5)：363-367,5.DOI:10.11952/j.issn.1007-1954.2017.05.003
经肝动脉化疗栓塞联合射频消融术对中晚期原发性肝癌的近期疗效分析
Therapeutic effects of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of advanced primary hepatocellular carcinoma
匡远黎 1王郑 1杨志亮 1谭智明1
作者信息
- 1. 重庆开州区人民医院 肝胆心胸外科,重庆 405400
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effects and safety of transcatheter arterial chemoembo-lization (TACE) combined with percutaneous radiofrequency ablation (RFA) in the treatment of advanced primary hepatocellular carcinoma (PHC). Methods A total of 125 cases of patients with advanced PHC were divided into the TACE group (n=40), RFA group (n=38) and TACE+RFA group (n=47) according to the different therapeutic methods. The short-term efficacy and complications of the three groups were observed. The recurrent rate, survival rate and median survival time (MST) were calculated by Kaplan-Meier method, and the differences among the three groups were analyzed by Log-Rank test. Results The total effective rate of the TACE+RFA group was 74.5%, which was obviously higher than those of the TACE group (52.5%) and the RFA group (47.4%) (P<0.05). The 1- and 2-year recurrent rates of the TACE+RFA group were 17.0% and 31.9%, respec-tively, which were both significantly lower than those of the TACE group (37.5% and 57.5%) and the RFA group (42.1% and 60.5%) (P<0.05). Moreover, the 1- and 2-year survival rates of the TACE+RFA group were 89.4%and 70.2%, respectively, which were both evidently higher than those of the TACE group (70.0% and 47.5%) and the RFA group (68.4% and 44.7%) (P<0.05). Additionally, the MST of the TACE+RFA group (26 months) was observably longer than those of the TACE group (21 months) and the RFA group (19 months) (P<0.05). Conclu-sion The therapy of TACE combined with RFA can improve the survival rate and prolong the survival time of advanced PHC patients, and it has a better therapeutic effect on advanced PHC than that of single TACE or single RFA.关键词
原发性肝癌/肝动脉化疗栓塞/射频消融术/介入治疗/疗效Key words
primary hepatocellular carcinoma/transcatheter arterial chemoembolization/radio frequency ab-lation/interventional therapy/therapeutic effect分类
医药卫生引用本文复制引用
匡远黎,王郑,杨志亮,谭智明..经肝动脉化疗栓塞联合射频消融术对中晚期原发性肝癌的近期疗效分析[J].肝胆胰外科杂志,2017,29(5):363-367,5.
