国际医药卫生导报2017，Vol.23Issue(18)：2906-2909,4.DOI:10.3760/cma.j.issn.1007-1245.2017.18.029
常规MR和弥散加权成像对原发性中枢神经系统淋巴瘤和胶质母细胞瘤的鉴别诊断价值
Value of conventional MR and diffusion weighted imaging in differentiating primary central nervous system lymphoma and glioblastoma
李冬 1李振1
作者信息
- 1. 277000 枣庄市薛城区人民医院放射科
- 折叠
摘要
Abstract
Objective To evaluate the role of conventional magnetic resonance (MR) imaging and diffusion weighted imaging (DWI) in differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM).Methods Conventional MR and DWI images of 27 patients with GBM and 22 patients with PCNSL were retrospectively analyzed.The mean apparent diffusion coefficient (ADC) of the tumor and contralateral white matter were measured,and the corrected ADC value was calculated (ADCC =ADC tumor/ADC contralateral white matter).Visual signal characteristics on T1WI and T2WI between PCNSL group and GBM group were compared by chi square test,the ADCM and ADCC value between the two groups were compared by t test.Receiver operating characteristic (ROC) curve were used to determine the diagnostic value of ADCM and ADCC in differentiating PCNSL from GBM.Results There was statistically significant difference in the enhancement homogeneity between the PCNSL group and the GBM group (P＜0.01),while there were no statistically significant differences in the signal characteristic on T1WI (P =0.06) and T2WI (P =0.86) between the PCNSL group and the GBM group.GBM showed significantly higher ADCM and ADCC values than PCNSL group [(0.97:t:0.17)x 10 3 mm2/s vs.(0.69+0.11)× 103 mm2/s,(1.28±0.21) vs.(0.92±0.13);P＜0.01].ROC curve indicated that setting ADCM ≤＜0.85 × 10-3 mm2/s as threshold value,optimal diagnostic ability could be obtained (AUC:0.911;sensitivity:95.5％;specificity:81.5％);setting ADCC ≤＜1.09 as threshold value,optimal diagnostic ability could be obtained (AUC:0.936;sensitivity:95.5％;specificity:85.2％).Conclusion DWI could aid in the differentiating diagnosis between PCNSL and GBM,which provides supplementary information for conventional MR imaging.关键词
原发性中枢神经系统淋巴瘤/胶质母细胞瘤/磁共振成像/弥散加权成像/鉴别诊断Key words
Primary central nervous system lymphoma/Glioblastoma/Magnetic resonance imaging/Diffusion weighted imaging/Differential diagnosis引用本文复制引用
李冬,李振..常规MR和弥散加权成像对原发性中枢神经系统淋巴瘤和胶质母细胞瘤的鉴别诊断价值[J].国际医药卫生导报,2017,23(18):2906-2909,4.
