广西植物2017，Vol.37Issue(9)：1204-1212,9.DOI:10.11931/guihaia.gxzw201706018
不同储存条件对大麻化学稳定性的影响
Effects of storage conditions on the chemical potency of Cannabis
摘要
Abstract
Cannabis is one of the most common drugs of abuse worldwide. The major cannabinoids in cannabis plants are relatively unstable and their contents may vary in different storage conditions. The aim of the present study was to investi-gate the effects of light and temperature on the stability of cannabinoids in Cannabis plants. The levels ofΔ9-tetrahydro-cannabinol (Δ9-THC) , cannabinol ( CBN) and cannabidiol ( CBD) in different chemical phenotypes cannabis powders and methanol extracts were respectively measured for up to 20 d storage in natural light at laboratory temperature ( 22 ±2)℃ and in darkness at laboratory temperature (22 ± 2)℃, 4℃ and-20℃, using the method of ultra-high perform-ance liquid chromatography (UPLC-PDA). The results showed that the changes in contents of the three cannabinoids in different chemical phenotypes were the same. The degradation ofΔ9-THC and CBD were pronounced and the content of CBN was almost unchanged for the solid samples exposed to light at ( 22 ± 2)℃. The contents of Δ9-THC, CBN and CBD in methanol extracts exposed to light at (22 ± 2)℃ were significantly decreased. Cannabis plants and Cannabis ex-tracts can be stored in darkness at laboratory temperature ( 22 ± 2)℃, 4℃ and -20℃. The degradation of the main psychoactive component Δ9-THC in Cannabis satisfied the rule of first-order reaction kinetics, and the above-mentioned regular pattern was used to study the change of the contents of Δ9-THC in different storage conditions. It is concluded that light is an important factor affecting the degradation ofΔ9-THC. Cannabis powders or extracts are reasonably stable if stored in the dark at room temperature. It is better to guide the collection, transportation, preservation and identifica-tion of Cannabis materials in judicial practice in a short period of time.关键词
大麻/Δ9-四氢大麻酚/大麻酚/大麻二酚/稳定性/降解动力学Key words
Cannabis/Δ9-tetrahydrocannabinol (Δ9-THC)/cannabinol ( CBN)/cannabidiol ( CBD)/stability/deg-radation kinetics分类
农业科技引用本文复制引用
孙维来,赵彦彪,郑晓雨,曾令华,高利生,刘耀,郑珲..不同储存条件对大麻化学稳定性的影响[J].广西植物,2017,37(9):1204-1212,9.基金项目
国家重大仪器研发专项项目(2012YQ12004910) [Supported by the National Key Instrument Program (2012YQ12004910)]. （2012YQ12004910）
