解放军医药杂志2017，Vol.29Issue(8)：93-96,4.DOI:10.3969/j.issn.2095-140X.2017.08.025
瑞舒伐他汀联合法舒地尔对破裂颅内动脉瘤栓塞术后患者DCVS发生率、MCA流速及生活质量的影响
Effects of Rosuvastatin Combined with Fasudil on DCVS Incidence Rate, MCA Blood Flow Velocity and Quality of Life of Patients with Ruptured Intracranial Aneurysms after Embolization
摘要
Abstract
Objective To investigate effects of Rosuvastatin combined with Fasudil on delayed cerebral vascular spasm (DCVS) incidence rate,middle cerebral artery (MCA) blood flow velocity and quality of life of patients with ruptured intracranial aneurysms after embolization.Methods A total of 120 patients with ruptured intracranial aneurysms after embolization during March 2014 and March 2016 were divided into control group (n =60) and observation group (n =60) according to treatment methods.Control group was treated with Rosuvastatin only,while observation group was treated with Rosuvastatin combined with Fasudil.DCVS incidence rate,MCA blood flow velocity,Barthel index scores,Glasgow coma score (GCS),classification conditions of Glasgow outcome scale (GOS) and incidence rate of adverse reaction before and after treatment were compared in two groups.Results DCVS incidence rate in observation group was significantly lower than that in control group (P ＜ 0.05).After treatment,values of MCA blood flow velocity,Barthel index scores and GCS were significantly higher than those before treatment in both groups (P ＜ 0.05),and the above values in observation group were significantly higher than those in control group (P ＜ 0.05).The postoperative GOS classification in observation group was significantly better than that in control group (P ＜ 0.05).There was no significant difference in incidence rate of adverse reaction between two groups (P ＞ 0.05).Conclusion Rosuvastatin combined with Fasudil in treatment of patients with ruptured intracranial aneurysms after embolization can efficiently avoid the DCVS occurrence,increase levels of cerebral blood perfusion,improve quality of life and clinical outcomes without aggravating adverse drug reactions.关键词
法舒地尔/瑞舒伐他汀/颅内动脉瘤/血管痉挛,颅内Key words
Fasudil/Rosuvastatin/Intracranial aneurysm/Vasospasm, intracranial分类
医药卫生引用本文复制引用
王鹏,林涛,车海江..瑞舒伐他汀联合法舒地尔对破裂颅内动脉瘤栓塞术后患者DCVS发生率、MCA流速及生活质量的影响[J].解放军医药杂志,2017,29(8):93-96,4.基金项目
陕西省社会发展科技攻关项目(20155F006) （20155F006）
