河北医学2017，Vol.23Issue(9)：1448-1452,5.DOI:10.3969/j.issn.1006-6233.2017.09.012
利奈唑胺万古霉素治疗耐甲氧西林金黄色葡萄球菌感染的疗效及安全性分析
The Effect and Safety of Linezolid and Vancomycin on Methicillin-resistant Staphylococcus Aureus Infection
摘要
Abstract
Objective:To investigate the efficacy and safety of linezolid and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus ( MRSA) pneumonia. Methods: 60 patients with methicillin-resistant Staphylococcus aureus ( MRSA ) pneumonia were enrolled from January 2016 to March 2017 were randomly divided into two groups according to the random number table. The patients in the control group were treated with vancomycin, The patients in the experimental group were treated with linezolid, and the overall treatment efficiency, the white blood cell concentration before treatment and the concentration of C-reactive protein and the incidence of adverse reactions were compared between the two groups. Results:Compared with the control group, the total effective rate of the experimental group was significantly higher than that of the control group (P <0.01). After treatment, WBC and CRP were significantly lower than those before treat-ment, the difference was significant, and there was no significant difference between the two groups before and after treatment.WBC and CRP were significantly lower than those in the control group (P <0.05). There was no significant difference in the adverse reaction rate between the experimental group and the control group, ( P> 0.05) , while the experimental group of patients mainly diarrhea, nausea and other gastrointestinal adverse reactions, the control group of patients mainly to skin reactions, renal dysfunction adverse reactions. Conclu-sion:The efficacy of linezolid in the treatment of MRSA pneumonia is lower than that of vancomycin, and it is better to control inflammatory response, and the total effective rate of treatment is higher. The treatment of lin-ezolid is mainly caused by diarrhea, nausea and so on. Gastrointestinal adverse reactions, and vancomycin treatment of patients mainly to skin reactions, renal dysfunction adverse reactions, two groups of less adverse reactions, higher safety, worthy of clinical promotion, with reference.关键词
利奈唑胺/万古霉素/耐甲氧西林金黄色葡萄球菌/疗效/安全性Key words
Linezolid/Vancomycin/Methicillin-resistant staphylococcus aureus/Efficacy/Safety引用本文复制引用
高永民..利奈唑胺万古霉素治疗耐甲氧西林金黄色葡萄球菌感染的疗效及安全性分析[J].河北医学,2017,23(9):1448-1452,5.基金项目
青海省自然科学基金项目,(编号:20060112) （编号:20060112）
