郑州大学学报（医学版）2017，Vol.52Issue(5)：522-526,5.DOI:10.13705/j.issn.1671-6825.2017.05.002
食管鳞癌肿瘤最大长径与浸润深度(T分期)的关系
Relationship between the maximum tumor length and invasion depth ( T Stage) in esophageal squamous cell carcinoma
摘要
Abstract
Aim:To characterize the relationship between the maximum tumor length ( MTL) and invasion depth ( T stage) of esophageal squamous cell carcinoma (ESCC) for clinical T stage classification and precision treatment .Methods:A total of 21712 cases of ESCC consisted of 13009 males and 8703 females.MTL and depth of infiltration(T stage) for each patient were recorded based on surgical specimen measurement and light microscopy observation .The decision tree model based on SPSS software was applied to determine the cut-off point of MTL .Spearman rank correlation and logistic re-gression were used to analyze the relationship between MTL and T stage. Re sults:The average MTL for 21712 ESCC pa-tients was 0.2-16.5(4.1 ±1.7) cm.Spearman rank correlation analysis indicated a positive correlation between MTL and T stage (rS =0.355, P<0.001).Logistic regression analysis showed that the risk of T 2 and T3 increased 7.146 times in the patients with a cut-off value of MTL>3.9 cm(95%CI=6.449-7.918, P<0.001).The average MTL in male pa-tients was higher than that in females [(4.2 ±1.8) cm vs (3.9 ±1.6) cm,P<0.001].An apparent positive correlation of MTL and T stage was observed both in males (rS =0.341, P<0.001) and females(rS =0.369, P<0.001).Logistic regression analysis indicated that the risk of T 2 and T3 increased at the cut-off value of MTL>3.9 cm both in males and fe-males(male:7.251 times, 95%CI=6.343-8.288, P<0.001;female:7.315 times, 95%CI=6.234-8.584, P<0.001).Conclusion:The present study demonstrates a positive correlation between MTL and T stage in ESCC .MTL>3.9 cm is a sensitive cut-off point to reflect the severity of T stage .关键词
食管鳞癌/肿瘤最大长径/浸润深度/T分期Key words
esophageal squamous cell carcinoma/maximum tumor length/depth of infiltration/T stage分类
医药卫生引用本文复制引用
吕双,鲁建亮,王苒,周福有,王立东,宋昕,赵学科,陈培楠,范宗民,胡守佳,程让,杜丹凤,张向阳..食管鳞癌肿瘤最大长径与浸润深度(T分期)的关系[J].郑州大学学报（医学版）,2017,52(5):522-526,5.基金项目
国家自然科学基金委员会和广东省联合重大项目资助U1301227 （）
河南省科技重大专项资助 161100311300 （）
