郑州大学学报（医学版）2017，Vol.52Issue(5)：527-531,5.DOI:10.13705/j.issn.1671-6825.2017.05.003
M2型肿瘤相关巨噬细胞浸润与食管鳞癌发生、浸润及转移的关系
Relationship of infiltration of M2 type tumor-associated macrophages with oc-currence , invasion and metastasis of esophageal squamous cell carcinoma
摘要
Abstract
Aim:To investigate the relationship between the infiltration of M 2 type tumor associated macrophages ( M2 type TAM) and the occurrence , invasion and metastasis of esophageal squamous cell carcinoma ( ESCC) and its possible mechanism.Methods:The expressions of CD206, IL-8, MCP-1 proteins and IL-8, MCP-1 mRNA were detected using im-munohistochemical method and in situ hybridization in 50 cases of the interstitial of ESCC and 50 cases of normal esophage-al mucosa.Results:The number of M2 type TAM in the interstitial of ESCC was significantly higher than that in normal e-sophageal mucosa tissue(P=0.032);the positive expression rates of IL-8,MCP-1 protein and mRNA in the interstitial tis-sue of ESCC were significantly higher than those in the interstitial tissue of normal esophageal mucosa (P<0.05).The number of M2 type TAM was significantly associated with the depth of tumor invasion , lymph node metastasis and TNM stage(P<0.05), but not with the patients′age or gender(P>0.05).The number of M2 type TAM in ESCC was positive-ly correlated with the expressions of IL-8,MCP-1 protein(rP =0.432,0.315) and mRNA(rP =0.373,0.332,P<0.05). Conclusion:M2 type TAM may be related with the occurrence , invasion and metastasis of ESCC , and the mechanism may be related with chemotactic factor IL-8 and MCP-1 secreted by M2 type TAM.关键词
肿瘤相关巨噬细胞/CD206/IL-8/MCP-1/浸润转移Key words
tumor associated macrophage/CD206/IL-8/MCP-1/invasion and metastasis分类
医药卫生引用本文复制引用
张冰,孙淼淼,韦娜,贺璐璐,王正洋,张红新,陈奎生..M2型肿瘤相关巨噬细胞浸润与食管鳞癌发生、浸润及转移的关系[J].郑州大学学报（医学版）,2017,52(5):527-531,5.基金项目
河南省重点科技攻关计划项目 132102310086 （）
河南省基础与前沿技术研究计划项目 142300410076 （）
国家自然科学基金 81272370 （）
