郑州大学学报（医学版）2017，Vol.52Issue(5)：567-570,4.DOI:10.13705/j.issn.1671-6825.2017.05.012
氧化石墨烯-二氧化钛纳米材料对吲哚菁绿稳定性及体内分布的影响
Influence of graphene oxide-titanium dioxide nanomaterial on the stability and in vivo distribution of indocyanine green
李文武 1张晓戈 2祝杏 2张慧娟2
作者信息
- 1. 河南省食品药品评价中心 郑州450018
- 2. 郑州大学药学院药物分析教研室 郑州450001
- 折叠
摘要
Abstract
Aim:To investigate the influence of graphene oxide-titanium dioxide nanomaterial ( TiO2-GO) on the sta-bility and in vivo distribution of indocyanine green ( ICG) .To explore the possibility of TiO 2-GO/ICG used for cancer treat-ment as a photosensitizer .Methods:UV-Vis absorption spectrum was used to evaluate the impact of storage time and laser irradiation on the stability of ICG and TiO 2-GO/ICG.The effects of TiO2-GO on in vivo distribution of ICG were observed in 4T1 tumor-bearing mice by intravenous injection .Results:The results showed that TiO 2-GO could enhance storage stabili-ty of ICG at room temperature and under near-infrared laser irradiation .As a nanomaterial , TiO2-GO could significantly im-prove the in vivo distribution of ICG and enhance its accumulation in the tumor .Conclusion: TiO2-GO can improve the phototherapy effect of ICG by enhancing its stability and tumor accumulation .关键词
吲哚菁绿/氧化石墨烯-二氧化钛纳米材料/紫外-可见吸收光谱/稳定性/体内分布Key words
indocyanine green/graphene oxide-titanium dioxide nanomaterial/UV-Vis absorption spectra/stability/in vivo distribution分类
医药卫生引用本文复制引用
李文武,张晓戈,祝杏,张慧娟..氧化石墨烯-二氧化钛纳米材料对吲哚菁绿稳定性及体内分布的影响[J].郑州大学学报（医学版）,2017,52(5):567-570,4.
