湖南中医药大学学报2017，Vol.37Issue(9)：973-976,4.DOI:10.3969/j.issn.1674-070X.2017.09.014
丹白涂膜剂对黄褐斑患者皮肤屏障功能修复的临床研究
Repairing Effects of Danbai Coating Agent on Skin Barrier Function in Patients with Chloasma
摘要
Abstract
Objective To observe the clinical effect of Danbai coating agent in the treatment of chloasma and the repair of skin barrier function. Methods 100 patients were randomly divided into treatment group and control group, 50 cases in each group. Patients in the treatment group were smeared Danbai coating agent every night, once daily. The control group was coated with 2％ hydroquinone cream, once a night. After 3 months of treatment, the clinical efficacy of the two groups was e-valuated and analyzed. The skin water content, TEWL value and skin melanin content of the patients in the two groups before treatment, after 1 month and 3 months of treatment were analyzed. Results After 3 months of treatment, the effective rate of the treatment group was 68％, and that of the control group was about 52％. The difference between the two groups was sig-nificant (P<0.05). After one month of treatment, the water content of stratum corneum significantly increased and the TEWL value decreased significantly in the treatment group (P<0.05). The stratum corneum water content in the control grouo decreased significantly, and the TEWL value increased significantly (P<0.05). There was significant difference between the two groups (P<0.05). After 3 months of treatment, the skin corneum water content in treatment group significantly increased compared with the treatment for 1 month, TEWL significantly decreased (P<0.05). In the control group, the stratum corneum water content of the skin and TEWL value had no significant difference than treatment for 1 month (P>0.05). The skin corneum water content of the treatment group was significantly higher than that of the control group (P<0.05), the TEWL value was significantly lower than that of the control group (P<0.05). The amount of skin melanin in the two groups decreased than before treatment, and there was no significant difference between the two groups (P>0.05). Conclusion Danbai coating agent shows better effect than 2％ hydroquinone cream in treatment of chloasma and better repairing effect on the skin barrier function of patients.关键词
黄褐斑/丹白涂膜剂/皮肤屏障功能/角质层含水量/经皮失水值/黑色素量Key words
chloasma/Danbai coating agent/skin barrier function/water content of cuticle/percutaneous losing water/amount of melanin分类
医药卫生引用本文复制引用
陈宝清,郭岱炯,杨玉峰,钱方..丹白涂膜剂对黄褐斑患者皮肤屏障功能修复的临床研究[J].湖南中医药大学学报,2017,37(9):973-976,4.基金项目
广东省中医药强省科研课题(20141241). （20141241）
