湖南中医药大学学报2017，Vol.37Issue(9)：977-981,5.DOI:10.3969/j.issn.1674-070X.2017.09.015
乳腺癌TAC丑时化疗对化疗毒副作用影响的研究
Study of Toxicities of TAC Choushi (1:00-3:00) Chemotherapy for Breast Cancer
摘要
Abstract
Objective To evaluate the hematology and non hematologic toxicity and its safety of Choushi (1:00-3:00) chemotherapy through the comparison of Choushi chemotherapy and regular time chemotherapy. Methods The patients of breast cancer were randomly divided into two groups, 30 cases in the observation group and 30 cases in the control group. The two groups were given three courses of TAC/TEC regimens. The observation group was given chemotherapy at Choushi (1:00-3:00), the control group was received chemotherapy at regular time (14:30-17:30). The safety and toxicities of Choushi chemotherapy was evaluated by monitoring the blood routine, hepatic and renal function, nausea, electrocardiogram of patients. Results In three TAC/TEC chemotherapy courses, the degree of nausea and vomiting in observation group was lower than the control group (P<0.05). The hemoglobin, platelet, and aminotransferase (ALT, AST) between the two groups were not signifi-cantly different (P>0.05). Besides monitoring indicators, there was no trend of accidents, such as allergic reactions, cardiac toxicity and the peripheral nervous system toxicity and renal toxicity. Conclusion Choushi chemotherapy is better than regular chemotherapy in reducing nausea and vomiting caused by neoadjuvant chemotherapy TAC/TEC. Choushi chemotherapy could effectively alleviate the side effects caused by neoadjuvant chemotherapy TAC/TEC, and this method is safe.关键词
乳腺癌/丑时化疗/TAC/TEC/毒副作用Key words
breast cancer/chronotherapy at 12:30-17:30/TAC/TEC/toxic and side effects分类
医药卫生引用本文复制引用
何晓璐,谢丹..乳腺癌TAC丑时化疗对化疗毒副作用影响的研究[J].湖南中医药大学学报,2017,37(9):977-981,5.基金项目
广东省中医药管理局项目(2011B031700038). （2011B031700038）
