四川大学学报（自然科学版）2017，Vol.54Issue(4)：845-850,6.DOI:10.3969/j.issn.0490-6756.2017.04.030
二芳胺基呋喃甲酰胺类化合物的合成设计及抗菌活性研究
Design, synthesis and antifungal activity of novel furancarboxamide analogues containing a diarylamine moiety
摘要
Abstract
Carboxylic amides are one of the most important classes of agricultural fungicides.To discover new carboxylic amide analogues with high activity against plant pathogenic fungi,twenty novel furancarboxamide analogues containing a diarylamine moiety were designed,synthesized and characterized by 1 H NMR.Their antifungal activities in vitro were evaluated against four phytopathogenic fungi(Rhizoctonia solani,Sclerotinia sclerotiorum,Pythium aphanidermatum and Fusarium oxysporum) by mycelium growth inhibition method.Most compounds showed significant antifungal effect on R.solani and S.sclerotiorum,however,slightly weak antifungal effect on P.aphaniderrmatum and F.oxysporum.Compound li exhibited the most potent antifungal effect on S.sclerotiorum with EC50 value of 1.9229mg/L,superior to commercial fungicides boscalid (EC50 =2.6736 mg/L) and lead fungicide fenfuram (EC50 =9.9667 mg/L).The present work demonstrated that furancarboxamide analogues containing a diarylamine moiety could be used as a lead structure for further developing novel fungicides.关键词
呋喃甲酰胺类化合物/二芳胺/合成/抑菌活性/EC50Key words
Furancarboxamide analogues/Diarylamine/Synthesis/Antifungal activity/EC50分类
农业科技引用本文复制引用
王宏宇,张肖肖,高续恒,金洪,陶科,侯太平..二芳胺基呋喃甲酰胺类化合物的合成设计及抗菌活性研究[J].四川大学学报（自然科学版）,2017,54(4):845-850,6.基金项目
“十三五”国家重点研发计划课题(2016YFC0502004) （2016YFC0502004）
