生物加工过程2017，Vol.15Issue(5)：48-56,9.DOI:10.3969/j.issn.1672-3678.2017.05.006
代谢工程改造大肠杆菌生产乳酸的研究进展
Progresses in the metabolic engineering of Escherichia coli for lactic acid production
摘要
Abstract
As the simplest hydroxyl acid,lactic acid is one of the most important organic acids in food, pharmaceutical,cosmetic and chemical industries.More importantly,it is used to produce polylactic acid (PLA),a biodegradable polymer of great interest because it can be produced from renewable means and biodegradable in nature. Presently, lactic acid can be synthesized either chemically or by microbial fermentation. However, microbial fermentation has some potential advantages in using renewable substrates,high optical purity and environmentally friendly process. There are many strains capable of producing lactic acid such as Escherichia coli, Lactobacillus, Bacillus coagulans and Corynebacterium glutamicum.Owing to a rapid doubling time and growth rate,and the availability of excellent genetic tools for strain improvement,E. coli strains have been developed for effective production of D- and L-lactic acid using a metabolic engineering approach. This review describes the physicochemical properties of lactic acid as well as the state of its research and application. Furthermore,we focus on recent efforts devoted to metabolic engineering of E.coli for the production of lactic acid. Also,this review presents the guidelines for further developments in lactic acid production using E.coli.关键词
大肠杆菌/乳酸/代谢工程/细胞工厂Key words
Escherichia coli/lactic acid/metabolic engineering/cell factory分类
生物科学引用本文复制引用
张利华,陈献忠,沈微,樊游..代谢工程改造大肠杆菌生产乳酸的研究进展[J].生物加工过程,2017,15(5):48-56,9.基金项目
中央高校基本科研业务费专项资金(JUSRP51611A) （JUSRP51611A）
