同位素2017，Vol.30Issue(3)：204-208,5.DOI:10.7538/tws.2017.youxian.003
腺苷A2A受体显像剂11C-KW6002的合成与初步生物学评价
The Synthesis and Evaluation of 11C-KW6002 as the PET Adenosine 2A Receptor Imaging Agent
摘要
Abstract
PET with selective adenosine 2A receptor (A2A) radiotracers can be used to study a neurodegenerative disorders in vivo and to diagnose of PD.The PET radiotracer ne-KW6002 for imaging A2A was synthesized and evaluated,in normal and PD module rats.The results showed that the labeling yield was 56％ (decay corrected yield,n=-3) when 11CH3-Triflate reacted with nor-KW6002 under NaOH.The radiochemical purity of product was 99.50％ with specific activity of 1.5 × 1014 Bq/g.The balance of radioactivity in striatum was observed in normal rats with microPET.A significant raised radioactivity on the striatum of lesion compared with the normal side.The radioactivity was found absence on the striatum of lesion with 11C-CFT.11C-KW6002 is a potential PET radiotracer for imaging A2A.关键词
腺苷A2A受体/11C-KW6002/合成/microPET/显像剂Key words
A2A receptors/11C-KW6002/synthesis/microPET/imaging agent分类
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闫赋琴,周卫华,孙小萌,刘晓军..腺苷A2A受体显像剂11C-KW6002的合成与初步生物学评价[J].同位素,2017,30(3):204-208,5.
