摘要
Abstract
Objective To observe the effects of Chaihulonggumuli Decoction combined with Western medicine in the treatment of schizophrenia in senile female patients and the impacts on related cytokines:Methods A total of 80 senile female patients with schizophrenia were selected and randomly divided into a study group and a control group (n=40,respectively).The study group was treatment with Chaihulonggumuli Decoction combined with aripiprazole and the control group with aripiprazole.The course of treatment lasted for eight weeks.At the end of the second,fourth and eighth week before and after the treatment,the scores of brief psychiatric rating scale (BPRS),the scale for the assessment of positive symptoms (SAPS) and the scale for the assessment of negative symptoms (SANS) in the patients were detected;enzyme linked immunosorbent assay (ELISA) was applied to detect the serum IL-6,IL-8 and TNF-α levels in patients.Results After the treatment,the BPRS,SAPS and SANS scores in the two groups gradually decreased with the extension of treatment time(P ＜ 0.01),but the scores at each time points in the study group were significantly lower than those in the control group (P ＜ 0.01);at the end of eight weeks of treatment,the IL-6,IL-8 and TNF-α levels in the two groups were significantly lower than those before the treatment (P ＜ 0.05),while the decrease in the study group was greater than that in the control group (P ＜ 0.05).Conclusion Chaihulonggumuli Decoction combined with aripiprazole can effectively improve the effects in the treatment of schizophrenia in senile female patients.The reduction of the levels of serum IL-6,IL-8 and TNF-α may be one of the mechanisms of action.关键词
精神分裂症/老年女性/柴胡龙骨牡蛎汤/疗效/细胞因子Key words
schizophrenia/senile female patient/Chaihulonggumuli Decoction/effect/cytokine分类
医药卫生
