中国当代儿科杂志2017，Vol.19Issue(10)：1051-1055,5.DOI:10.7499/j.issn.1008-8830.2017.10.004
早产儿出生时血清25-羟维生素D水平与支气管肺发育不良的相关性
Association between serum 25(OH)D levels at birth and bronchopulmonary dysplasia in preterm infants
摘要
Abstract
Objective To assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and bronchopulmonary dysplasia (BPD) in preterm infants. Methods This study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were classified into two groups: BPD and control. The association between serum 25(OH)D levels at birth and BPD was analyzed. Results Serum 25(OH)D levels in the BPD group was significantly lower than those in the control group [(37±17 nmol/L vs 47±20 nmol/L; P<0.05), and the rate of vitamin D deficiency was significantly higher than those in the control group (90.2% vs 74.0%; P<0.05). The level of serum 25(OH)D was negatively correlated with the incidence of BPD (r=-0.201, P=0.001). Conclusions Vitamin D deficiency at birth may be associated with BPD in preterm infants, but need to be further studied by multivariate analysis.关键词
25-羟维生素D/支气管肺发育不良/早产儿Key words
25-Hydroxyvitamin D/Bronchopulmonary dysplasia/Preterm infant引用本文复制引用
余仁强,陈道桢,周勤,王敏,梅英姿,姜善雨..早产儿出生时血清25-羟维生素D水平与支气管肺发育不良的相关性[J].中国当代儿科杂志,2017,19(10):1051-1055,5.基金项目
江苏省临床医学科技专项(BL2014025) （BL2014025）
江苏省卫生计生委妇幼健康科研项目(F201427) （F201427）
江苏省妇幼保健重点学科项目(FXK201213) （FXK201213）
无锡市"科教强卫工程"医学重点学科、医学青年人才项目(ZDXK003、QNRC039). （ZDXK003、QNRC039）
