中国美容医学2017，Vol.26Issue(9)：71-74,4.
曲安奈德注射联合激光治疗对皮肤血管瘤患儿血清VEGF和HIF-1α的影响
Effect of Triamcinolone Acetonide Injection Combined with Laser Therapy on Serum VEGF and HIF-1 Alpha in Patients with Infantile Cutaneous Hemangioma
丁佐国 1冒进成 1赵艳霞1
作者信息
- 1. 如皋市人民医院皮肤科 江苏 如皋 226500
- 折叠
摘要
Abstract
Objective To evaluate vascular endothelial growth factor (VEGF) expression and hypoxia-inducible factor 1α (HIF-1α)expression in patients'serum treated with laser combined with injection of triamcinolone acetonide. Methods 95 proliferating hemangioma infantstreated with laser combined withtriamcinolone acetonide from January 2014 to October 2016 were engaged in this study. 30 normal control infants collected from the department of pediatrics served as the healthy controls. VEGF and HIF-1αexpression in the plasma were measured by ELISA. Statistical analysis was done by two-way analysis of variance followed by the least significantly difference (LSD) test. Results The serum level of VEGF in control group was (257.391±76.612 )μg/L, and the serum level of HIF-1α in control group was (2.975±1.045)mg/L. The serum levels of VEGF and HIF-1α in hemangioma patients before treatment were (416.849±104.219)μg/L and (12.347±1.463 )mg/L respectively.After 4 weeks treatment, the serum levels of VEGF and HIF-1αwere decreased to(285.402±122.457)μg/L (P<0.05) and (7.425±0.877)mg/L (P<0.05).After 12 weeks treatment,the serum levels of VEGF and HIF-1αwere decreased to(241.873±115.694)μg/L (P<0.05) and (2.414±1.948) mg/L (P<0.05) respectively. Conclusion The serum levels of VEGF and HIF-1α were decreased significantly after the laser combined with injection of triamcinolone acetonide treatment. VEGF and HIF-1α may be the objective index to evaluate the effect of the laser combined with injection of triamcinolone acetonide treatment on infant hemangiomas.关键词
皮肤血管瘤/曲安奈德/激光治疗/缺氧诱导因子/血管内皮生长因子Key words
triamcinolone acetonide/laser therapy/Baby/hemangiomas/vascular endothelial growth factor/hypoxia-inducible factor 1α分类
医药卫生引用本文复制引用
丁佐国,冒进成,赵艳霞..曲安奈德注射联合激光治疗对皮肤血管瘤患儿血清VEGF和HIF-1α的影响[J].中国美容医学,2017,26(9):71-74,4.
