中国畜牧兽医2017，Vol.44Issue(5)：1321-1328,8.DOI:10.16431/j.cnki.1671-7236.2017.05.010
脂滴发育中代谢相关的结构蛋白研究进展
Research Progress on Metabolic Related Structural Proteins in Lipid Droplet Development
摘要
Abstract
Generally,lipid droplets are storage of triglycerides in adipocytes,but recent resear-ches indicate that the transport,storage and steatolysis mobilization of fat in the cells are all based on lipid droplets,various phenomena reveal that lipid droplets is not only a simple energy storage in cells,but also more of a multifunctional organelle.By analyzing the structure of lipid droplets,it has been found that with neutral fat as the core,lipid droplets are covered with single phospholipid and embedded with a variety of functional proteins,which are referred as lipid drop-lets associated proteins.Lipid droplets associated protein correlated with lipid droplets are in-volved in the regulation of lipid metabolism,membrane transport,signal transduction and other physiological processes in different forms.It can be divided into three categories according to the different bearing capacity of proteins,including lipid droplet structural protein,lipid droplet as-sociated protein and lipid transport protein.Among them,structural proteins,such as proteins in the PAT family and CIDE family proteins,play important roles in the regulation of lipid droplet growth and metabolism.In addition,hormone-sensitive lipase,adipose triglyceride lipase and Rab protein,as well as other metabolism and transport proteins are suggested to be involved in lipid droplets development through different forms.At present,new types and mechanisms of lipid droplets related proteins are still being explored.This review is to address the research progress of lipid droplets,lipid metabolism and lipid droplets related proteins in cells.关键词
脂滴/代谢/脂滴相关蛋白Key words
adipocyte/metabolism/lipid droplet associated protein分类
生物科学引用本文复制引用
雒诚龙,邵伟,赵艳坤,余雄..脂滴发育中代谢相关的结构蛋白研究进展[J].中国畜牧兽医,2017,44(5):1321-1328,8.基金项目
新疆青年科技创新人才培养工程(GN2015YX014) （GN2015YX014）
新疆维吾尔自治区重点实验室开放课题(2015KL018) （2015KL018）
中国博士后基金委资助 （）
