北华大学学报（自然科学版）2017，Vol.18Issue(5)：603-605,3.DOI:10.11713/j.issn.1009-4822.2017.05.009
金针菇多糖对D-半乳糖衰老小鼠学习记忆能力的影响
Effect of Polysaccharides of Flammulina velutipes on Learning and Memory Ability in Aging Mice Induced by D-galactose
摘要
Abstract
Objective To study the effect of polysaccharides of Flammulina velutipes ( FVP ) on the learning and memory ability and the morphology of brain in aging mice. Method Sixty ICR mice, thirty males and thirty females,were randomly divided into six groups according to their body weights. They were blank control group, model group,piracetam group,low-dose FVP group,medium-dose group and high-dose group,and were raised for six weeks. Just after the last lavage,the passive avoidance test was conducted. In the final experiment,the mice were sacrificed and the morphology of mice brain was observed. Results Compared with those in the model group,the step-through latencies of mice in low-and high-dose groups were significantly prolonged (P<0. 05) in dark-avoidance test,and the number of error were significantly decreased (P<0. 05);compared with that in the model group,the number of nerve cells was significantly increased and the morphological structure of nerve cells was significantly improved in low-and high-dose FVP groups. Conclusion FVP may play an important role in the memory improvement in mice,can maintain the normal morphological structure of nerve cells of aging mice, and has protective effects on the brain tissues in aging mice induced by D-galactose.关键词
金针菇多糖/衰老/学习记忆Key words
FVP/aging/learning and memory ability分类
医药卫生引用本文复制引用
姜秀梅,徐小磊,杨聪,于亚男,张萌,许瑞英,姜琦..金针菇多糖对D-半乳糖衰老小鼠学习记忆能力的影响[J].北华大学学报（自然科学版）,2017,18(5):603-605,3.基金项目
吉林市科技发展计划项目(201536061) （201536061）
大学生国家级创新项目(201410201058) （201410201058）
大学生校级创新项目(201500152). （201500152）
